Neurology
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Is Autologous Bone Marrow Cell Therapy a Potential Treatment for Traumatic Brain Injury?
This study proposes that autologous bone marrow mononuclear intravenous infusion for severe traumatic brain injury in children appears safe and potentially may be efficacious.
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Enlargement of Choroid Plexus in Subacute COVID-19 Patients
The authors of this study hypothesized that there likely is enlargement of the choroid plexus in patients with COVID-19 infections.
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Insights into Restless Legs Syndrome from Genome-Wide Meta-Analyses
This genome-wide association study’s meta-analysis, performed in a large European-ancestry cohort, identified 164 risk gene loci for restless legs syndrome. Some of the loci point to potential new drug therapies, but there also was strong evidence of currently unknown environmental factors that influence the expression of various genes.
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Being Mindful of COVID’s Effects on Cognitive Decline
A large observational study finds objective evidence of lingering cognitive deficits associated with past COVID-19 infection, particularly in patients infected early in the pandemic, those hospitalized, or those with prolonged illness duration.
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Disorders of Immunity Are a Risk Factor for Herpes Simplex Virus Encephalitis
The current study of herpes simplex virus (HSV) encephalitis demonstrated an association of encephalitis with preexisting autoimmune disease and/or exposure to immunosuppressive and immunomodulatory medications. The findings underscore the potential underestimation of antecedent immune-related dysregulation in HSV encephalitis cases to date.
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Efgartigimod for Seronegative Myasthenia Gravis
In an uncontrolled, open-label series of patients with myasthenia gravis, double antibody-negative patients responded to immunosuppressive therapies in a similar manner as do those with antibodies to acetylcholine receptors (AChR) or muscle-specific tyrosine kinase. However, when treating myasthenia patients with a specific agent (efgartigimod) that blocks AChR antibodies at the level of endothelial cells, double antibody-negative patients do not respond as well.
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Usefulness of the Physical Examination in the Concussed Patient
This article suggests that certain specific physical examination findings may be helpful in evaluating and monitoring patients with sports-related concussion using oculovestibular responses and balance tests.
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Intensive Lifestyle Interventions May Prevent and Ameliorate the Symptoms of Alzheimer’s Disease
Recent clinical studies support the benefit of intensive lifestyle interventions, which should include a plant-based diet, exercise, stress management, and avoidance of smoking and alcohol, for the prevention of Alzheimer’s disease.
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Results from GLP-1 Receptor Agonists in Early Parkinson’s Disease
This paper demonstrated that after one year of treatment, lixisenatide resulted in less progression of motor disability. Longer studies are needed to determine if this represents true disease modification.
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Brentuximab Neuropathy
Brentuximab, an antibody-drug conjugate for the treatment of lymphomas, carries a high risk of inflammatory sensory and motor neuropathies.