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In this contribution from Germany, Schulz and colleagues provide an annotated, referenced table of therapeutic, toxic, and potentially fatal blood concentrations of nearly 1000 drugs and other xenobiotics (substances foreign to the body that may be ingested or otherwise reach the circulation).
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The use of non-steroidal anti-inflammatory drugs (NSAIDs) early after myocardial infarction (MI) has been shown to increase the risk of death or recurrent MI, but little is known about the long-term risks. Thus, this group from Denmark evaluated their national database and identified more than 99,000 patients who survived 30 days after discharge following their first MI.
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In this single-center, prospective study, median duration of antibiotics for community-acquired pneumonia (CAP) decreased from 10 to 7 days with an antibiotic stewardship program that included education and prospective feedback to the managing team.
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Zolpidem and risk of falls; AVR and anticoagulation; statins in cancer patients; and FDA actions.
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In the first report (Newland et al), a quasi-experimental study with a control group (also known as a nonrandomized, postintervention design) was performed from 20042010 to determine the impact of an antimicrobial stewardship program (ASP) implemented in March 2008 in a tertiary care childrens hospital that was based on prospective-audit-with-feedback. The control group included 25 childrens hospitals.
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Family members who received a diary written during their family members ICU admission had lower levels of symptoms related to post-traumatic stress disorder.
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A history of cancer in a patient with ischemic stroke often raises additional concerns for the clinician, including assessment of cancer activity, as well as possible thrombophilias. The use of thrombolytic agents is also controversial in patients with active cancers.
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Investigators of the stroke arrhythmia monitoring Database in Erlangen, Germany, performed continuous telemetric cardiac rhythm monitoring on 501 acute stroke patients admitted to their stroke unit.