Neurology
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Statins, Cognitive Decline, and Dementia
An analysis of the ASPREE database showed that with almost five years of follow-up, statins are not associated with cognitive decline or dementia in a large group of elderly subjects in whom multiple tests of cognition were performed serially. -
Semaglutide Injection (Wegovy)
Semaglutide can be prescribed as an adjunct to a low calorie diet and increased physical activity for chronic weight management in overweight and obese adults. -
Blood Culture Contamination: Risks and Adverse Effects
In addition to identifying several patient risk factors for contamination of blood culture specimens, the authors also highlighted various adverse clinical and financial adverse effects. -
Long-Term Effects of Cholinesterase Inhibitors on Cognitive Decline, Mortality
Cholinesterase inhibitors are one of the few drug classes approved by the FDA to treat patients with Alzheimer’s disease. This study shows a long-term benefit in slowing the decline of cognition, but it is unclear if there is any benefit in quality of life. -
Party Affiliation and Social Distancing
Disparate public health messaging from political officials, news media, and online outlets has occurred throughout the COVID-19 pandemic in the United States. Some have wanted to ascribe lower rates of compliance with public health guidance to political affiliation. -
Extensive Loss of Health at Six Months in Survivors of COVID-19
Researchers found many survivors of COVID-19 exhibited significant loss of health six months after their acute illness, with greater risk associated with severity of the acute infection. -
Is a History of Palpitations Useful for Detecting Atrial Fibrillation?
An analysis of the utility of implanted loop recorders to detect subclinical atrial fibrillation in high-risk individuals showed that among common arrhythmia-compatible symptoms, only palpitation was predictive of discovering episodes of atrial fibrillation. -
Researchers Observe No Connections Between Statin Therapy, Cognitive Decline
But randomized trials are needed to better detail long-term risk-benefit ratio. -
Dietary Modifications with Linoleic Acid Can Have an Effect on Gut and Brain Inflammation
This study evaluated the use of dietary conjugated linoleic acid (CLA) supplementation to modulate the disease outcome in a spontaneous mouse model of central nervous system autoimmunity and also studied patients with relapsing-remitting multiple sclerosis receiving CLA supplementation. CLA may act as a modulator of the gut-brain axis by targeting immune cells in the gut, with a subsequent effect in the brain.
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Neuromuscular Complications of Graft-Versus-Host Disease
Graft-versus-host disease is common in allogeneic bone marrow recipients, but neuromuscular complications are unusual (8%). The most common neuromuscular complication is an immune-mediated myositis that responds to treatment with immunosuppressive therapies.