Neurology
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Insulin Glargine-yfgn Injection (Semglee)
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Anticoagulation Plus Antiplatelet Therapy in Chronic Atherosclerosis
An analysis of the COMPASS trial for the secondary endpoint of mortality showed the combination of low-dose rivaroxaban and aspirin significantly lowered the all-cause mortality rate vs. low-dose aspirin alone.
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No Harm in a Morning Cup of Joe
Habitual coffee consumption was inversely associated with a lower risk of cardiac arrythmia.
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Statins, Cognitive Decline, and Dementia
An analysis of the ASPREE database showed that with almost five years of follow-up, statins are not associated with cognitive decline or dementia in a large group of elderly subjects in whom multiple tests of cognition were performed serially.
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COVID-19 Vaccination: The Heart of the Matter
The occurrence of myocarditis after receipt of COVID-19 vaccines is most frequent in young men and generally benign, with rapid resolution only through supportive care. Careful analysis indicates the benefit of vaccination outweighs the risk in all groups for whom the vaccine is recommended.
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Treatment of Seizures After Spontaneous Intracerebral Hemorrhage
The reported incidence of post-stroke seizures varies and appears to have a higher incidence following hemorrhagic stroke. Post-stroke seizures have been associated with a greater length of hospitalization, increased mortality, and complications. This study compared four seizure prophylaxis strategies to determine the greatest net benefit for patients with spontaneous intracerebral hemorrhage. There was a better outcome with short-term antiepileptic medication use compared to long-term use.
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Cortical Lesions Correlate with Disability in Patients with Multiple Sclerosis
In a long-term, 30-year follow-up study of a cohort of patients with multiple sclerosis who presented with clinically isolated syndrome, the investigators found that, among the variables assessed, the presence of cortical lesions had the highest association with long-term physical and cognitive disability.
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Proteomics: A New Method to Understand the Influence of Genetic Variation on Disease Pathogenesis
The combination of genome-wide association studies with the analysis of messenger ribonucleic acid and unique proteins in the brain, cerebrospinal fluid, and plasma can shed new light on our understanding of the genetic risks for the development of various neurological diseases.
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What Is Focal CIDP?
Chronic inflammatory demyelinating polyneuropathy (CIDP) usually is diagnosed in patients who have a generalized disorder. However, there are focal syndromes that have been observed and diagnosed under different names that meet many of the clinical and electrodiagnostic criteria of CIDP and may be referred to as “focal” CIDP.
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MRI Changes and Functional Outcomes Among Adults with Severe HSV Encephalitis
Herpes simplex virus is a common cause of encephalitis worldwide. When treated promptly, the mortality rate decreases from 70% to 15%, but many patients remain disabled. This multicenter cohort study analyzed magnetic resonance imaging in patients diagnosed with herpes simplex encephalitis admitted to the intensive care unit to identify factors associated with poor outcome at 90 days.