Neurology
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Thienopyridine Pretreatment in Patients with Non-ST Elevation Acute Coronary Syndromes: Where’s the Evidence?
Each year when I lecture the incoming cardiology fellows on the management of non-ST elevation acute coronary syndromes (NSTE-ACS), we embark on a discussion of optimal guideline-driven treatment vs. real-world practicalities. -
If Less is More, How Can We Get There?
This study, done at a tertiary care university hospital here in the U.S., was initiated in an attempt to improve patient safety, conserve a vital resource, and reduce costs a laudable tripartite goal. -
Primary Care Reports - Full January 2015 Issue in PDF
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Side Effects of Opioids
More than 40% of ED visits are related to pain.1 The Joint Commission has made the assessment and treatment of pain in the ED one of its standards.2 The use of opioid medications has been increasing in both adults and children.3-5 In 2009 there were more than 200 million prescriptions for opioid medications, with enough medication dispensed to supply every adult in the United States with the equivalent of 5 mg of hydrocodone every four hours for one month.
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Clinical Briefs
Johnston BC, et al. Comparison of weight loss among named diet programs in overweight and obese adults: A meta-analysis. -
Updates and Future Direction on Medical Uses for Probiotics
The probiotic movement is rapidly growing and, although to date no probiotics have been approved by the FDA, they are actively marketed to the public as either foods or dietary supplements. It behooves the primary care physician to be familiar with the science, indications, and appropriate usage of probiotic therapies. -
Stroke Alert
Carotid MRI scanning was performed in 1414 stroke-free participants, older than the age of 45 years, to assess the morphology of any atherosclerotic plaques, specifically to look at the presence of a lipid core, intraplaque hemorrhage, calcification, or fibrous tissue in each carotid artery. -
Anti-Titin Antibodies in Myasthenia Gravis
In addition to autoantibodies directed against the acetylcholine receptor (AchR) and the receptor-associated protein muscle-specific tyrosine kinase (MuSK) patients with myasthenia gravis (MG) demonstrate a host of other antibodies. -
Hypoperfusion Response During Cortical Spreading Depolariz
This study examines and describes the occurrence of an inverse neurovascular coupling response in peri-contusional brain tissue as a potential and novel mechanism for secondary brain injury. -
Aspirin for the Prevention of Recurrent Venous Thromboembolism
Patients with unprovoked venous thromboembolism (VTE) are at high risk of recurrence after discontinuation of vitamin K antagonist (such as warfarin) therapy, with an approximately 10% risk of recurrence within the first year and 5% risk per year thereafter.