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Although studies in animals and preliminary reports in patients with ARDS suggested that statin administration might be beneficial in patients with the syndrome, this multicenter, double-blind clinical trial showed no benefit from simvastatin by any measure examined.
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In this study of administrative data from patients admitted to 421 U.S. hospitals with acute chronic obstructive pulmonary disease (COPD) exacerbations, 41% received long-acting bronchodilators, which are not recommended in this setting. Comparison with patients who did not receive the long-acting agents showed no evidence for clinical or economic benefit from their use.
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Based on a recent systematic review of the literature, clinical guidelines were developed by the American Association of Blood Banks with the goal of providing platelet transfusion thresholds for adult patients in common clinical scenarios.
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In a longitudinal population-based study, metformin use was associated with an increased incidence of low thyroid-stimulating hormone (TSH) levels in patients with treated hypothyroidism.
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This article originally appeared in the November 29, 2014, issue of Internal Medicine Alert. It was edited by Stephen A. Brunton, MD, and peer reviewed by Gerald Roberts, MD. Dr. Brunton is Adjunct Clinical Professor, University of North Carolina, Chapel Hill, and Dr. Roberts is Senior Attending Physician, Long Island Jewish Medical Center, NS/LIJ Health Care System, New Hyde Park, NY.
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Patent foramen ovale (PFO) is common in both the general population, as well as in patients with cryptogenic stroke, with an estimated prevalence somewhere between 15-35%. Recurrent neurovascular events, both recurrent ischemic stroke as well as transient ischemic attacks, are frequent in these patients, but it is not clear whether patients with PFOs have an increased rate of recurrent events compared to those patients who do not have PFOs.
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he Choosing Wisely Campaign was introduced in 2011 by the American Board of Internal Medicine to identify practices and procedures physicians and patients should question. The critical care top 5 list was developed through a collaborative effort of several critical care societies.
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