Neurology
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Diagnostic Utility of CSF Alpha-Synuclein
This observational study investigated whether the cerebrospinal fluid (CSF) α-synuclein (α-syn) real-time quaking-induced conversion (RT-QuIC) assay, applied to 289 CSF samples, accurately identified patients with mild cognitive impairment (MCI) caused by probable Lewy body (LB) disease. RT-QuIC identified patients with MCI-LB against cognitively unimpaired controls with 95% sensitivity, 97% specificity, and 96% accuracy and showed 98% specificity in neuropathologic controls, indicating that CSF α-syn RT-QuIC is a robust biomarker for prodromal dementia with Lewy bodies.
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Surgical Approaches to Decompression in Degenerative Lumbar Spondylolisthesis
A multicenter, randomized, noninferiority trial of people with symptomatic lumbar stenosis and single-level spondylolisthesis who were refractory to conservative treatment found no significant difference between outcomes in those who underwent decompression surgery with instrumented fusion vs. decompression surgery without fusion.
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COVID-19 Vaccine mRNA Injection (Comirnaty)
Comirnaty is the first COVID-19 vaccine to receive full FDA approval.
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Functional Cognitive Disorder: An Important Condition to Recognize
Functional cognitive disorder (FCD) can describe cognitive difficulties that are present where there is no biologic cause, but a lack of consensus in diagnostic criteria limits its use in clinical practice and research. The authors proposed an operational definition for FCD as the cognitive phenotype of functional neurological disorder.
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Vitamin and Mineral Supplements for Cardiovascular Disease
A meta-analysis of systematic reviews and randomized, controlled trials to analyze the role of commonly used dietary supplements for prevention and treatment of cardiovascular disease suggests no significant effect on cardiovascular outcomes or all-cause mortality, although some B vitamins appear to reduce stroke incidence, and B3 appears to increase all-cause mortality.
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Fermented Foods Help the Immune System, Alleviate Inflammation
A diet rich in fermented foods from dairy and other sources reduced 19 inflammatory markers compared with a high-fiber diet.
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Asymptomatic Transmission of COVID-19 in Households
Efforts to control secondary transmission should be given to households and those contact groups where any case of secondary transmission has been identified.
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Combined GIP/GLP-1 Agonist: Safe for Type 2 Diabetes Patients?
In the SURPASS-2 trial, tirzepatide showed noninferiority and superiority vs. semaglutide in decreasing A1c levels in patients with type 2 diabetes.
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IRBs Facing Ethically Controversial Questions on Brain Research
The field of brain research sounds a lot like science fiction, but human neural organoids, human neural transplants, and human-animal chimeras all are imminent realities. IRBs are going to be facing some difficult decisions on whether this research can proceed. The authors of a recent report examined these issues.
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Is This Ventricular Tachycardia?
The ECG in the figure was obtained from an elderly man with chest pain and shortness of breath. Is the rhythm ventricular tachycardia?