Neurology
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Atogepant for Migraine Prevention
Atogepant, an oral small-molecule inhibitor of the calcitonin gene-related peptide pathway, administered once daily, effectively reduced migraine days in the preventive treatment trial of migraine over a period of 12 weeks.
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Rapid Eye Movement Sleep Duration Is Predictive of Life Expectancy
Total sleep duration declines with older age, as does the fraction of sleep spent in rapid eye movement (REM) sleep. The decline in REM is associated with increasing mortality, but it is unclear if this is a cause or a marker of declining health and declining brain function.
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Ethics of 10-Year Research Agenda for Dementia, Alzheimer’s Studies
There is a pressing need for more research on non-cure-based treatments for people living with dementia. That gap in is a real ethical concern. Social-behavioral research can help family members who are struggling to figure out where the loved one with dementia is going to live.
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Difelikefalin Injection (Korsuva)
Difelikefalin can be prescribed to treat moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis.
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SARS-CoV-2 Rapid Antigen Testing in a Nursing Home Outbreak
Rapid antigen testing was accurate in detecting SARS-CoV-2 antigen when compared to polymerase chain reaction.
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Localized Slow Wave Sleep in the Awake but Inattentive Brain
Electroencephalogram studies of humans during periods of “mind wandering” and “mind blanking” have shown regional changes that suggest parts of the brain may be asleep while other areas are activated.
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Why Exercise Alone Does Not Result in Fat Loss
To lose body fat, a ketogenic weight loss diet must be combined with exercise.
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Updated 2021 Sexually Transmitted Infections Treatment Guidelines
The CDC updated their sexually transmitted infections treatment guidelines with new recommendations for Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, pelvic inflammatory disease, and Mycoplasma genitalium.
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In Addition to the Rhythm
The ECG in the figure was obtained from a middle-aged woman who presented with a febrile illness and shortness of breath. She reported no chest pain. In addition to the rhythm, what else is going on?
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Dihydroergotamine Nasal Spray (Trudhesa)
DHE nasal spray can be prescribed to treat migraine in adults with or without aura.