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Evaluation of the clinical course of the 21,094 eligible U.S. male physicians in the Physicians' Health Study revealed that an elevated BMI in both pre-obese and obese subjects was associated with an increased risk of CHF and that vigorous physical activity was associated with a decreased risk of CHF.
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Proton pump inhibitors given concomitantly with clopidogrel administered after acute myocardial infarction appear to diminish the beneficial effects of clopidogrel, thus increasing the risk of re-infarction.
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In this issue: Individualization of therapy with pharmacogenetics; the rate vs rhythm debate; the FDA's Risk Evaluation and Mitigation Strategy; FDA actions.
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The goals of this study were fourfold: 1) to increase implementation rates of evidence-based interventions that have been shown to reduce ICU mortality and morbidity; 2) to design tools to promote team communication and team building; 3) to develop prompts that could be incorporated into an ICU progress note to promote consistent use of these measures; and 4) to provide "real time"' feedback regarding progress.
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To determine whether relationships existed between the use of clinical information technology (CIT) and measures of patient outcomes, Amarasingham and colleagues conducted a cross-sectional study of urban hospitals in Texas using the questionnaire-based Clinical Information Technology Assessment Tool, which measures a hospital's level of automation based on the interactions of its physicians with the information system.
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The effects of selective digestive tract decontamination (SDD) and selective oropharyngeal decontamination (SOD; SDD without systemic antibiotics), which are measures for preventing ICU-acquired infections, on patient outcomes and microbial resistance patterns remain unsettled and controversial.
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Patman and associates at the Lung Institute of Western Australia in Perth undertook this study to determine whether the routine, intensive administration of chest physiotherapy (PT) to mechanically ventilated patients with severe acute brain injury would prevent the occurrence of ventilator-associated pneumonia (VAP), or speed its resolution once it was present.
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Hough et al set out to determine incidence and outcomes of early neuromyopathy in patients with persistent acute respiratory distress syndrome (ARDS), and to evaluate the association of neuromyopathy with the use of methylprednisolone in this population.