Neurology
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Atogepant Tablets (Qulipta)
Atogepant can be prescribed to prevent episodic migraine in adults.
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Progression of Coronary Calcium on Statin Treatment
In those treated with statins vs. those who were not, statins decreased plaque volume in plaques with little or no calcium (plaque regression) and increased calcium density without changes in plaque volume in calcified plaques (plaque stabilization).
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Adjuvanted Zoster Vaccine: Persistent Protection
The adjuvanted recombinant zoster vaccine efficacy is high and persistent, with apparent plateauing at > 84% four to six years after vaccination.
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First-Line Therapy for Hypertension
When comparing angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs) to treat hypertension, researchers observed no difference in major cardiovascular events — but a better safety profile for ARBs.
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Carbohydrates and Insulin Resistance: Pondering Food Quality vs. Quantity
Researchers posit that solving the obesity epidemic is not as simple as eating less and moving more.
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Electrodiagnostic Findings in Thoracic Outlet Syndrome
The diagnosis of thoracic outlet syndrome may be difficult and relies on specific clinical, imaging, vascular, and electrodiagnostic features. None of the currently recommended treatments have been shown to be effective, but there are few randomized clinical treatment trials.
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Is Pimavanserin Safe to Use in Patients with Parkinson’s Disease?
This retrospective cohort study of patients with Parkinson’s disease ages 65 years or older residing in Medicare-certified long-term care facilities revealed pimavanserin use vs. nonuse is associated with an increased risk of 30-day hospitalization and higher 90-, 180-, and 365-day mortality.
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Neurodegenerative Ataxia: Improvement in Motor and Cognitive Outcomes with Cerebello-Spinal Stimulation
Concurrent cerebellar and spinal stimulation with a transcranial direct current stimulation device resulted in improvement of both motor and cognitive functions in patients with several different forms of neurodegenerative ataxia.
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Study: Interferon Does Not Help Hospitalized COVID-19 Patients
When combined with remdesivir, the multiple sclerosis drug did not produce clinical benefit.
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Is the Suicidality Class Warning Warranted for Antiseizure Medications?
This study reports data that refutes the U.S. Food and Drug Administration’s class warning regarding suicidality risk in patients with epilepsy who are taking the newer antiepileptics, approved since 2008. The class warning should be reconsidered.