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Every intensivist recognizes that families play a prominent role in ICU decision making.
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Prior studies have demonstrated that delayed transfer of critically ill patients from the emergency department (ED) to the ICU (> 6 hours) prolongs ICU and hospital stay.
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Prone positioning has been advocated as a management strategy for patients with acute respiratory distress syndrome (ARDS), but despite evidence of improved oxygenation with the technique, numerous studies have yet to establish a mortality benefit from the practice.
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In this issue: Statin and niacin increase HDL-C, omeprazole reduces effectiveness of clopidogrel, darbe-poetin increases risk of stroke, statins decrease risk of gallstone disease, FDA Actions.
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Early goal-directed therapy (EGDT) has been shown to reduce hospital mortality from severe sepsis and septic shock. Puskarich et al hypothesized that long-term outcome would also be improved.
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The FDA has approved the first treatment for relapsed or refractory peripheral T-cell lymphoma. Pralatrexate, an inhibitor of dihydrofolate reductase, was granted accelerated approval by the FDA. It will be marketed by Allos Therapeutics as Folotyn™.
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The ECG shown above was obtained from a 72-year-old woman as a baseline. How would you interpret her ECG? How many blocked and early findings can you identify?
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The antiplatelet effect of clopidogrel is dependent upon its conversion and activation through the 2C19 pathway of the P450 system. Blockade of this pathway occurs because of genetics, in persons who do not have sufficiently active 2C19, and pharmacotherapies that specifically block 2C19. Proton pump inhibitors (PPIs), particularly omeprazole, are recognized to be 2C19 inhibitors. Is there reason for concern?
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Cholinesterase inhibitors place patients at risk for syncope, bradycardia, permanent pacemaker insertion, and hip fracture.