Neurology
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In Addition to Vaccination, Can More Be Done to Prevent Severe COVID-19?
Using data for more than 1.2 million Americans who completed primary vaccination against COVID-19, severe disease outcomes were rare; however, vaccinated persons aged ≥ 65 years with immunosuppression or other underlying conditions were found to be at higher risk.
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Nutritional Interventions for Prodromal Alzheimer’s Disease
Over a 36-month period, patients with prodromal Alzheimer’s disease who consumed Fortasyn Connect (Souvenaid), a nutraceutical drink, demonstrated a slower decline in cognitive functions vs. the control group.
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Researchers to Test Groundbreaking Treatment for Intracerebral Hemorrhage-Type Strokes
Clot-busting drugs can be used to treat patients with ischemic strokes, but there are no good pharmacological alternatives for patients with intracerebral hemorrhages (ICH). This is a concerning treatment gap because ICH-type stroke outcomes can be dire. The creators of a new trial are testing whether a drug already used in other applications can offer benefits to patients with ICH strokes.
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Is Physical Activity Associated with Mortality Risk in Parkinson’s Disease?
In individuals with Parkinson’s disease (PD), physical activity (PA) at all intensities is associated with reduced all-cause mortality, with the greatest reduction seen in individuals who maintained PA before and after PD diagnosis.
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The Effect of Disease-Modifying Therapies for Multiple Sclerosis on the Immune Responses to COVID-19 Vaccination
An analysis of a large group of patients with multiple sclerosis taking various disease-modifying therapies showed that the response to COVID-19 vaccination was not uniform across the therapies. Patients taking anti-CD20 therapies and fingolimod had attenuated responses to vaccines.
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Diet and the Risk of Dementia
Specific dietary patterns, such as the Mediterranean-style diet, have been shown to promote brain health, mitigate neuro-inflammation, and reduce the risk of dementia. This prospective cohort study demonstrated an association between a high inflammatory potential diet and increased risk for incident dementia.
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Acute Muscle Weakness in Children: Acute Flaccid Myelitis or Guillain-Barré Syndrome?
Compared to children with Guillain-Barré syndrome, children with acute flaccid myelitis have a more rapid presentation to nadir of weakness, fewer sensory abnormalities, and an inflammatory spinal fluid early in the course.
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The Effect of Epilepsy on Patients with Brain Tumors
Cancer cells form direct synapses with neurons, whose electrical activity stimulates brain tumor growth. Accumulating evidence suggests that epilepsy enhances the proliferation of malignant brain tumors and that improved management of epilepsy may reduce morbidity and mortality in these patients.
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Neurology Groups Update Position on Stroke and Informed Consent
Experts provide updated ethical guidance on decision-making capacity, emergency treatment, and clinical research.
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Inclisiran Injection (Leqvio)
Inclisiran can be prescribed as an adjunct to diet and maximally tolerated statin therapy for adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease who required additional low-density lipoprotein cholesterol lowering.