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Both nitazoxanide and the investigational anionic polymer, tolevamer, may have efficacy comparable to that of standard therapies in the treatment of CDAD. The addition of rifampin to metronidazole is not superior to treatment with metronidazole alone.
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A medical research unit in the United Kingdom analyzed 18 different strategies for managing patients with suspected DVT.
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The SPARCL study showed that 80 mg per day of atorvastatin reduced the overall incidence of recurrent stroke, and a meta-analysis of several large studies of ACE inhibitors showed a reduction in all stroke types, as well as a reduction in overall cardiovascular mortality.
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Transfers of care can be problematic if critical information is not shared when responsibility transitions between clinicians. Although such "hand-offs" create the opportunity for error, transfer management in United States hospitals has never been described on a national level.
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TNF Blockers: Should You Be Concerned?; FDA Actions
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In the early 2000s, substantial evidenced-based interventions were added to the care of critically ill patients that significantly reduced mortalityincluding low tidal volume ventilatory support for acute respiratory distress syndrome (ARDS), protocolized sedation with daily awakening, Drotrecogin-alpha for severe sepsis, tight glycemic control, corticosteroids for refractory septic shock and preventative strategies for ventilator associated pneumonia.
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In this prospective observational study, Kollef and associates enrolled patients with ventilator-associated pneumonia (VAP) in 20 ICUs across the United States in order to characterize the patients and the antimicrobial regimens used in treating them, as well as their mortality and lengths of stay.
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In this randomized-controlled trial, Koeman and associates wanted to determine the effect of two oral decontaminating gels, chlorhexidine 2% (CHX) or chlorhexidine 2% plus colistin 2% (CHX/COL), compared to a placebo, on the development of ventilator-associated pneumonia (VAP) in patients requiring more than 48 hours of mechanical ventilation.