Neurology
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Anchoring Alzheimer’s Disease Along an Amyloid Timeline
In 601 individuals from Wisconsin-based cohorts with amyloid-beta and tau positron emission tomography scans, the magnitude and topographical spread of tau pathology increased with longer duration of amyloid-beta positivity, and the cognitive decline was steepest in those with the longest duration of amyloid-beta positivity and elevated entorhinal tau.
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CSF Analysis May Help in the Diagnosis of Dementia with Lewy Bodies
This paper demonstrated that cerebrospinal fluid (CSF) alpha-synuclein seeding assays can distinguish between clinically diagnosed dementia with Lewy bodies and controls, and that the presence of hyposmia with core clinical features had the highest predictive value of detecting CSF alpha-synuclein.
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Anchoring Alzheimer’s Disease Along an Amyloid Timeline
In 601 individuals from Wisconsin-based cohorts with amyloid-beta and tau positron emission tomography scans, the magnitude and topographical spread of tau pathology increased with longer duration of amyloid-beta positivity, and the cognitive decline was steepest in those with the longest duration of amyloid-beta positivity and elevated entorhinal tau.
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Clinical Criteria for a Limbic-Predominant Amnestic Neurodegenerative Syndrome
Predominant limbic degeneration in older geriatric patients (ages 75 years and older) with slowly progressive episodic memory loss with fluorodeoxyglucose-positron emission tomography medial temporal hypometabolism limbic-predominant age-related TDP-43 encephalopathy (LATE) involves a progressive degeneration of the amygdala, then hippocampus, then middle frontal gyrus.
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Can Large Vessel Strokes Be Treated with IV Thrombolysis in an Extended Time Window?
In this trial involving Chinese patients with ischemic stroke caused by large vessel occlusion, treatment with tenecteplase administered 4.5 to 24 hours after stroke onset resulted in less disability and similar survival compared to standard medical treatment.
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Incidental Cerebral Microinfarcts in Patients with Active Cancer
In this study of patients with active cancers, 3.6% had asymptomatic, incidental acute ischemic stroke lesions on magnetic resonance imaging and had three times the risk of having a subsequent clinical stroke in the next month.
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Donanemab-azbt (Kisunla)
The U.S. Food and Drug Administration has approved the third anti-amyloid beta monoclonal antibody for the treatment of Alzheimer’s disease, following aducanumab and lecanemab.
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Utility of Electromyography in the Diagnosis of Rhabdomyolysis
Electromyography often is requested in the evaluation of a patient with rhabdomyolysis. It often shows evidence of “myopathy,” but muscle biopsies frequently are non-confirmatory, and genetic testing often is needed for a definitive diagnosis.
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Acute Clinical Worsening Without MRI Changes in Multiple Sclerosis
Patients with multiple sclerosis (MS) can have an acute clinical event suggestive of a relapse, but their magnetic resonance imaging (MRI) shows no corresponding changes (labeled by the authors as an acute clinical event with stable MRI [ACES]). These events have not been systematically analyzed. The authors reported that this number is significant, and a quarter of the relapses reported by patients fall under this category. Patients with ACES had higher relapse rates and a greater risk of transition to secondary progressive MS.
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Are New-Onset Seizures Associated with SARS-CoV-2 Vaccines?
In this meta-analysis, there was no statistically significant difference in the risk of new-onset seizure incidence between vaccinated individuals and placebo recipients in the 28-day post-injection period. Similarly, in the post-injection entire blinded phase (median follow-up 148, 121, and 43 days in three trials), no significant difference was observed between the vaccine and placebo recipients regarding the incidence of new developing seizures.