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The advances in understanding the genotype-phenotype associations for LRRK2 presented by these articles represent an important step towards this objective.
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Screening patients with a history of cerebral aneurysm and screening relatives of patients with familial aneurysms can detect new or recurrent aneurysms that may benefit from treatment.
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Mode of onset, distribution of symptoms, and electrophysiological characteristics may be prognostic factors for predicting a favourable outcome.
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This prospective 10-year study of 7356 patients with ST-elevation MI who presented in cardiogenic shock showed once again that early mechanical revascularization (as recommended by current guidelines) substantially increases survival; it also suggests that adherence to the guidelines needs to be further improved.
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Airway Management is an integral and frequent component of care of the critically ill.
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In a randomized, controlled trial, patients with stroke or head injury who required mechanical ventilation were less likely to develop ventilator-associated pneumonia if they underwent early percutaneous gastrostomy for nutritional support than if they continued to be fed via nasogastric tube.
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Both intra-abdominal hypertension and evidence for its adverse physiologic effects were common in this retrospective series of ICU patients with severe acute pancreatitis, although there was no association with mortality, and 3 of 4 patients subjected to decompressive laparotomy died.
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When study data were used to perform a formal analysis of costs associated with use of erythropoietin, the total cost to avoid one transfusion-related adverse event was $4.7 million.
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