Neurology
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Multiple Sclerosis Disease Burden May Be Underestimated
Prescription drug prices, indirect productivity loss drive care costs significantly higher for these patients compared to others.
Posterior Myocardial Infarction, or deWinter T Waves?
The ECG was taken from an older man who complained of chest pain over the past month. The pain severity was even worse on the day he underwent imaging. How would you interpret the ECG?
Dexmedetomidine Sublingual Film (Igalmi)
Dexmedetomidine can be prescribed for the acute management of agitation associated with schizophrenia or bipolar I or II disorder.
COVID-19 Vaccine and the Menstrual Cycle
In a retrospective cohort analysis of prospectively tracked menstrual cycle data from the smartphone application “Natural Cycles,” the COVID-19 vaccine was associated with a less than one day change in menstrual cycle length and no change in menses length.
The Association Between Cancer Mortality and Physical Activity for Middle-Aged and Older Patients
In a prospective cohort study of older U.S. adults, replacing sedentary behavior with physical activity was associated with a lower cancer mortality risk.
Postmenopausal Estrogen May Prevent Death from COVID-19 Infection
Swedish researchers found taking postmenopausal estrogen was associated with a lower death rate from COVID-19 infection. Taking estrogen suppression therapy for breast cancer was associated with a higher death rate compared with controls.
Neurodegeneration Biomarkers in Patients with Subjective Cognitive Complaints
In individuals with subjective cognitive decline, multiple biomarkers of neurodegeneration were found to add predictive values beyond amyloid and tau biomarkers; however, the various neurodegeneration biomarkers were not equivalent and should not be used interchangeably.
Antibody Profile in Refractory Myasthenia Gravis
In retrospective studies of patients with generalized myasthenia gravis, those who are refractory to multiple treatments have disease onset at an earlier age, are more likely to have thymic pathology, and are more likely to be double-seronegative (neither acetylcholine receptor nor muscle-specific receptor tyrosine kinase antibodies).
Outcomes of Progressive Multifocal Leukoencephalopathy Treated with IL-7
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the reactivation of the JC virus. The authors of this study conducted a multi-centered retrospective observational study on 64 patients with PML who were treated with recombinant human IL-7 (RhIL-7). Overall, the one-year all-cause survival following start of RhIL-7 was 55% and similar among human immunodeficiency virus/acquired immunodeficiency syndrome, hematological malignancies, and primary immunodeficiencies.
Does Amantadine Treatment Reduce Levodopa-Induced Dyskinesias?
This retrospective cohort study compared the effect of amantadine on levodopa-induced dyskinesia (LID) onset with use of anticholinergics and monoamine oxidase type B inhibitors in patients with Parkinson’s disease. The authors concluded that early treatment with amantadine may delay LID onset more than treatment with other symptomatic agents.