Neurology
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Beware the Cardiovascular Risks Associated with Thyroid Hormone Replacement Therapy
Thyroid levels outside the euthyroid range have been associated with higher cardiovascular risk in patients taking thyroid hormone to treat hypothyroidism. In this study, a higher cardiovascular mortality rate was associated with exogenous hyperthyroidism and exogenous hypothyroidism.
Did You See Both ECG Findings?
The ECG in the figure was obtained from an older man with new chest pain. There are two principal ECG findings on this tracing. Do you see both?
Oteseconazole Capsules (Vivjoa)
The FDA has approved the first drug to reduce recurrent vulvovaginal candidiasis.
Neurodegeneration Biomarkers in Patients with Subjective Cognitive Complaints
In individuals with subjective cognitive decline, multiple biomarkers of neurodegeneration were found to add predictive values beyond amyloid and tau biomarkers.
Does Amantadine Treatment Reduce Levodopa-Induced Dyskinesias?
Early treatment with amantadine may delay levodopa-induced dyskinesia onset more than treatment with other symptomatic agents.
COVID-19 Associated with Significant Increase in Hospital-Acquired Bloodstream Infections
The COVID-19 pandemic was associated with increases in hospital-onset bloodstream infections, mainly in patients with COVID-19.
Myositis as a Cause of Unexplained Dysphagia
A stepwise diagnostic algorithm was developed to identify potentially treatable idiopathic inflammatory myopathies in patients presenting with isolated unexplained dysphagia.
What Is the Right Dose of Immunoglobulin to Treat CIDP?
In this comparative trial of different doses of intravenous immunoglobulin treatment for chronic inflammatory demyelinating polyneuropathy, higher doses appeared to result in a higher percentage of patients who improved. However, there was no control group and there were many confounding issues that make it difficult to reach a definitive conclusion around optimal dosing.
Intensive Blood Pressure Control May Augment Cerebral Blood Flow
Patients with hypertension were randomized to intensive vs. standard blood pressure control and underwent baseline and follow-up cerebral perfusion imaging. Intensive blood pressure treatment was associated with improved cerebral perfusion over time.
Polygenic Associations of Chronic Axonal Polyneuropathy
In most cases of chronic axonal polyneuropathy, no specific cause is found. Using a polygenic risk score for potential risk factors, based on whole genome sequencing, these investigators identified multiple significant risk factors, including diabetes, body mass index, alcohol intake, and vitamin B12 level.