Neurology
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Outcomes of Progressive Multifocal Leukoencephalopathy Treated with IL-7
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the reactivation of the JC virus. The authors of this study conducted a multi-centered retrospective observational study on 64 patients with PML who were treated with recombinant human IL-7 (RhIL-7). Overall, the one-year all-cause survival following start of RhIL-7 was 55% and similar among human immunodeficiency virus/acquired immunodeficiency syndrome, hematological malignancies, and primary immunodeficiencies.
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Does Amantadine Treatment Reduce Levodopa-Induced Dyskinesias?
This retrospective cohort study compared the effect of amantadine on levodopa-induced dyskinesia (LID) onset with use of anticholinergics and monoamine oxidase type B inhibitors in patients with Parkinson’s disease. The authors concluded that early treatment with amantadine may delay LID onset more than treatment with other symptomatic agents.
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Cognitive Outcomes After Mild Traumatic Brain Injury
Mild traumatic brain injuries (mTBIs) may lead to adverse cognitive and neuropsychiatric outcomes. The pathways that lead to adverse cognitive outcomes remain to be scientifically elucidated. A prospective cohort study of 656 participants enrolled in the Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) study found that at one year, 13.5% of participants with mTBI had poor cognitive outcome compared to 4.5% of controls, highlighting the need for better understanding of the mechanisms leading to poor cognitive and functional outcomes after mTBIs and interventions to optimize cognitive recovery.
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Investigators Make Ethical Commitment for Neuroscience Research in Humans
There are overarching principles of ethical conduct of human neuroscience research, but the methods and implementations may vary across institutions.
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Donepezil Transdermal Patch (Adlarity)
Donepezil transdermal system can be prescribed to treat mild, moderate, and severe dementia of the Alzheimer’s type.
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Bloodstream Infections During COVID-19
Severity of illness, prolonged hospital stays, use of mechanical ventilation, and use of immune-modulating agents in patients with COVID-19 may have contributed to observed increases in hospital-acquired blood stream infections and attendant mortality.
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Empower Patients With Education Resources About Pelvic Floor Disorders
Online patient resources for pelvic floor disorders on the American Urogynecologic Society patient portal are underused by women with pelvic floor disorders.
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Gastrointestinal Bleeding on Anticoagulants: Predicting Colorectal Cancer in Afib Patients
A large Danish registry study showed that in atrial fibrillation patients on oral anticoagulants and who experience a lower gastrointestinal bleed, the incidence of a subsequent diagnosis of colorectal cancer is significantly higher than in those without bleeding.
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The Effects of Diet, Nutrition, and Weight on Fibromyalgia
This review of evidence for the use of dietary interventions to treat fibromyalgia shows symptom reduction associated with a variety of healthy diets. Weight loss may be key to understanding this connection, but more research is needed.
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It Is Uncertain if Men and Women Present with Different Symptoms at the Onset of Ischemic Stroke
There have been anecdotal reports and small case series that have suggested women may present with symptoms that are different from men at the onset of ischemic stroke or transient ischemic attacks. These investigators conducted a systematic review to determine if there was a difference in presenting symptoms between men and women.