Neurology
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What Is the Right Dose of Immunoglobulin to Treat CIDP?
In this comparative trial of different doses of intravenous immunoglobulin treatment for chronic inflammatory demyelinating polyneuropathy, higher doses appeared to result in a higher percentage of patients who improved. However, there was no control group and there were many confounding issues that make it difficult to reach a definitive conclusion around optimal dosing.
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Intensive Blood Pressure Control May Augment Cerebral Blood Flow
Patients with hypertension were randomized to intensive vs. standard blood pressure control and underwent baseline and follow-up cerebral perfusion imaging. Intensive blood pressure treatment was associated with improved cerebral perfusion over time.
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Polygenic Associations of Chronic Axonal Polyneuropathy
In most cases of chronic axonal polyneuropathy, no specific cause is found. Using a polygenic risk score for potential risk factors, based on whole genome sequencing, these investigators identified multiple significant risk factors, including diabetes, body mass index, alcohol intake, and vitamin B12 level.
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Use of Serum Biomarkers in Determining Prognosis After Cardiac Arrest
Used in conjunction with the clinical exam and brain imaging, serum biomarkers, such as neurofilament light, can help refine the prognostication for patients who have experienced severe anoxic/ischemic brain injury after cardiac arrest.
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Report: Pregnancy-Related Hypertensive Disorders Doubled in 12 Years
An estimated one in five births in the United States are affected by various adverse pregnancy outcomes.
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Major Traumatic Brain Injury Can Raise Dementia Risk
Patients with brain bleeding and a long hospital stay were 1.5 times more likely to develop dementia compared to those with no injury.
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Etafilcon A Drug-Eluting Contact Lens with Ketotifen (Acuvue Theravision with Ketotifen)
Ketotifen-eluting contact lens can be prescribed to correct refractive ametropia (myopia and hyperopia) for phakic or aphakic patients who wear suitable lens and experience ocular itch caused by allergic conjunctivitis.
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Women at Higher Risk for Intracranial Aneurysm Ruptures
Women with ruptured aneurysms were older than men, were less often smokers, and more often experienced internal carotid artery aneurysms. They also tended to produce larger-sized aneurysms than men.
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Men More Likely to Produce High-Risk, Dangerous Carotid Artery Plaques
Investigators found significant differences in mean total plaque volume between men and women. Men were more likely to experience intraplaque hemorrhage and produce lipid-rich necrotic cores with coexistence of calcifications. Men also were more likely to exhibit thin or ruptured fibrous caps or ulcerations in their atherosclerotic plaques.
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Pregnant, Influenza-Infected, and Hospitalized
Almost one-third of women age 15-44 years hospitalized with influenza were pregnant and almost 5% required intensive care.