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Episodes of severe sepsis in older adults is associated with worsening cognition and functional status.Source: Iwashyna TJ, et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010;304:1787-94.
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A 74-year retired veterinarian presents to the emergency department (ED) with shortness of breath. He was recently diagnosed with diffuse large-cell lymphoma with prominent abdominal lymphadenopathy and positive bone marrow and has been treated with two cycles of R-CHOP.
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In a multicenter study, critically ill patients with initial hyperlactatemia had improved outcomes (including shorter ICU stays and lower adjusted mortality) compared to control patients when they were managed for the first 8 hours with a resuscitation protocol targeted at reducing the lactate level by at least 20% every 2 hours.
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The relationship between blood pressure and cardiovascular events remains controversial, especially in patients with coronary artery disease who may need increased pressures to have adequate myocardial perfusion.
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Gastrointestinal (GI) bleeding is a major complication of dual anti-platelet therapy (DAPT) with aspirin and clopidogrel.
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Most adrenal masses found inadvertently as part of an investigation for another illness are benign. The work-up for an adrenal incidentaloma is presented.
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Acetaminophen is able to induce a significant increase in BP in ambulatory subjects with CAD.
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The surface ECG shows the net result of electrical forces that are operative. This concept is important to remember when potential "competing conditions" are operative.
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The FDA has approved a second dipeptidyl peptidase-4 (DPP-4) inhibitor and metformin combination. This follows the approval of sitagliptin/metformin in 2007.
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Sleep-deprived individuals appear less healthy, tired, and less attractive to untrained observers than when they are rested.