Neurology
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Active Life, Healthy Mind
Daily exercise, frequent social interactions, and even performing regular household chores can lower dementia risk.
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COVID-19 and Headache
Headache is a common feature of acute COVID-19 infection, as well as a long-standing feature of “long COVID” after recovery from the acute infection. Treatment is symptomatic, based on the characteristics of the headache syndrome.
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Myopathy Is Associated with Post-COVID-19 Fatigue
Prolonged fatigue after COVID-19 infection may be associated with evidence of myopathy, based on physical examination, electromyography, and muscle biopsy.
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Risk Factors Associated with Alzheimer’s Disease and Related Dementias in the United States
Two independent analyses of U.S. national surveys support evidence that targeted risk-reduction strategies may reduce the burden of Alzheimer’s disease in the population.
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Noradrenergic Drugs for the Symptomatic Treatment of Alzheimer’s Disease
This meta-analysis provides evidence that drugs modulating the noradrenergic system could be effective in treating cognitive symptoms and apathy in patients with Alzheimer’s disease.
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Thyroid Problems Could Raise Dementia Risk
Researchers recently observed an association between hypothyroidism and dementia.
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Genetic Evaluation of Hereditary Spastic Paraplegia
Hereditary spastic paraplegia (HSP) refers to a group of rare, clinically heterogenous degenerative neurogenetic disorders resulting in spasticity, gait impairment, and falls as the result of a length-dependent upper motor neuron degeneration. Next-generation sequencing with multigene panels or exome analysis can confirm molecular diagnosis of approximately 30% of HSP patients. Multigene panels can identify the common causative variants, variants on rarely involved genes, and structural rearrangements.
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Risk Factors and Outcomes for Post-Traumatic Seizures After Moderate to Severe Traumatic Brain Injury
Using data collected from an Australian registry, a population-based cohort study identified risk factors for early post-traumatic seizures (EPS), associated morbidity and mortality, and contribution to development of post-traumatic epilepsy (PTE). EPS were associated with significant in-hospital morbidity, poorer outcomes, and increased risk of mortality at 24 months of follow-up. Patients with EPS had a higher risk of developing PTE.
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How Should We Manage False-Positive Myasthenia Gravis Antibody Studies?
False-positive autoantibody tests for myasthenia gravis occur in a small number of patients who undergo broad screening for autoimmune disorders affecting the peripheral and central nervous system. Careful investigation of clinical and electrophysiological features of each patient will determine the validity of these tests.
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Mechanical Thrombectomy with or Without Intravenous Thrombolysis?
Current stroke treatment guidelines recommend combined use of intravenous thrombolysis with alteplase prior to endovascular thrombectomy for patients with large vessel occlusion. However, there continues to be controversy surrounding this recommendation, and these investigators undertook a systematic review and meta-analysis of completed therapeutic trials to help resolve the controversy.