Neurology
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Atypical Presentations for Inclusion Body Myositis
Inclusion body myositis, the most common acquired myopathy, often is misdiagnosed or diagnosed after a delay of many years. Atypical presentations are not unusual, and clinicians should maintain a high degree of suspicion for this disorder when patients present with slowly progressive muscle weakness in an unusual pattern.
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Early Respiratory Decline in Amyotrophic Lateral Sclerosis
Hypercapnia, a manifestation of early respiratory dysfunction, can be challenging to detect in amyotrophic lateral sclerosis (ALS) patients. Pulmonary function tests are helpful, but their specificity in detecting hypercapnia is low and their use is limited in patients with bulbar weakness. Specific symptoms, such as dyspnea at rest, dyspnea while talking, and use of medications for sleep, can be more reliable in detecting hypercapnia among ALS patients.
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Persistent Asthma Patients Show More Plaque Buildup, Inflammation
Pulmonary ailment could speed carotid artery damage, create more inflammatory biomarkers.
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Acute Ataxia and Gait Disturbances in the Emergency Department
Ataxia and gait disturbances can signify a variety of conditions. The differential includes benign as well as life-threatening causes. An understanding of the pathophysiology and a thorough neurological exam are critical in making these distinctions.
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Medical Incapacity Holds Require Ethical Oversight
Clinicians feel conflicted about their ethical obligations. On one hand, they know it is unsafe for a confused person to be allowed to walk out of the hospital. On the other hand, they are understandably worried about their legal risks.
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Sodium Phenylbutyrate and Taurursodiol for Oral Suspension (Relyvrio)
Relyvrio can be prescribed to treat amyotrophic lateral sclerosis in adults.
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Long-Term Outcomes in Intracerebral, Intraventricular Hemorrhage
It is important to avoid giving a poor prognosis early in the clinical course, and to continue supportive care until the long-term outcome truly is understood.
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Benefits, Risks of Dual Antiplatelet Therapy After Acute Ischemic Stroke or TIA
It will be important to determine the actual frequency of the CYP2C19 loss-of-function gene. Clinicians should consider point-of-care testing for patients before selecting and initiating dual antiplatelet therapy.
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Scientists Are Worried About Air Quality and Dementia Risk
Traffic-related air pollution raises red flags for neurological health.
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Long-Term Neurological Outcomes of Patients Treated with CAR-T Therapy
Chimeric antigen receptor (CAR)-T cell therapy is approved for the treatment of lymphoma, leukemia, and multiple myeloma, but its use is associated with early neurotoxicity in almost half of patients. Despite the incidence of neurotoxicity, long-term follow-up of patients after CAR-T infusion suggests that patients’ neurological examination, neuro-imaging studies, and cognition remain unaffected by this treatment.