Neurology
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Intracranial Clot Extraction Results in Better Outcomes than Intravenous Thrombolysis Alone
This article will discuss three studies that have been recently published in the New England Journal of Medicine — MR CLEAN, ESCAPE, and EXTEND — regarding intracranial clot extraction for acute ischemic stroke
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Restless Legs Syndrome and Post-polio Syndrome
Restless legs syndrome is prevalent in patients with post-polio syndrome and is associated with decreased quality of life and fatigue.
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Update in Treating Neuropathic Pain
In an exhaustive review of the literature with a meta-analysis, the following medications were found to be most efficacious in the treatment of neuropathic pain: gabapentin, pregabalin, serotonin-noradrenaline reuptake inhibitors including duloxetine or venlafaxine, and tricyclic antidepressants.
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‘The Butterfly Effect’ Explains Weather Triggering of Migraine
For about 13% of patients with migraine, a change in weather may be a trigger for some headaches; however, there is no specific perturbation in meteorological measures that is likely to predict a headache.
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Autologous Hematopoietic Stem Cell Transplant for Relapsing-Remitting MS
Interim analysis at 3 years post-treatment of a study of high-dose immunosuppression and autologous hematopoietic stem cell transplant for relapsing remitting-multiple sclerosis demonstrates sustained disease control but also shows potential risks associated with this treatment.
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Is Pediatric-onset Multiple Sclerosis a Neurodegenerative Disorder?
ABSTRACT & COMMENTARY: Pediatric-onset multiple sclerosis compromises age-expected brain growth.
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Clinical Briefs
Modifying the Home Environment to Prevent Falls
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Secukinumab Injection (Cosentyx™)
A recombinant, fully humanized monoclonal antibody to interleukin-17 has been approved for the treatment of moderate-to-severe plaque psoriasis. Secukinumab is marketed by Novartis as Cosentyx.
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B-type Natriuretic Peptides (BNP) Values Improve CVD Risk Prediction
Elevated BNP values in a large cohort of women with numerous CV events modestly improved measures of CVD risk prediction.
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Does a Link Exist Between OSA and CAD?
Obstructive sleep apnea is associated with coronary artery calcification in non-obese individuals, but the effect is largely attenuated by body mass index.