Neurology
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Clindamycin vs. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Infections
Cure rates did not differ between the treatments and rates of adverse events were similar in the two groups.
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Utility of the New Cholesterol Guidelines
The risk:benefit ratio is much better for moderate- than high-intensity statins.
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Risk of NSAID Use in Patients Receiving Antithrombotic Therapy After Myocardial Infarction
The use of NSAIDs was associated with increased risk of bleeding and excess thrombotic events, even after short-term treatment.
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Severe Alcoholic Hepatitis: Prednisolone or Pentoxifylline?
ABSTRACT & COMMENTARY: A clinical trial studied short- and medium-term mortality in patients admitted to the hospital for severe alcoholic hepatitis.
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Wide Tachycardia in a Patient with Chest Pain
The 12-lead ECG and accompanying long lead II rhythm strip in the Figure was obtained from a 70-year-old woman with chest pain. She was hemodynamically stable at the time this ECG was recorded. What is the rhythm? -
Clinical Briefs
Accumulation of briefs: Consequences of NSAID Use in Patients Receiving Post-MI Antithrombotic Prophylaxis, Psoriasis Is Associated with Insulin Resistance, and Difficult Questions About Testosterone and Mortality
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Steroids for Severe Community-Acquired Pneumonia: More Evidence or More Uncertainty?
Community-acquired pneumonia (CAP) is the leading cause of mortality from infection in industrialized countries, and treatment failure occurs in 10-20% of cases despite appropriate antibiotic therapy. Thus, effective treatment strategies that reduce the burden of CAP would have a major impact on public health. Several previous studies that investigated the role of corticosteroids in CAP produced mixed results. Torres and colleagues hypothesized that corticosteroids modulate the immune response in severe CAP, thereby decreasing treatment failure.
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Effects of Lifestyle Modifications on the Coronary and Carotid Atherosclerotic Burden
A look at how lifestyle changes, including dietary modifications and regular exercise, impact therapy for atherosclerotic cardiovascular disease.
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Diet Sodas: Are They Really Diet?
Over the past several decades, concerns about increased sugar consumption has led some experts to recommend the use of non-nutritive sweeteners (NNSs).1
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Endovascular Intracranial Clot Extraction Benefits Are Confirmed in Two More Clinical Trials
On April 17, 2015, the New England Journal of Medicine published the results of two randomized clinical trials of endovascular stent-retriever clot extraction for ischemic stroke, simultaneous with their presentation at the European Stroke Conference. These two studies, added to those presented and published at the International Stroke Conference in February, bring the total number of studies to five that have shown dramatic benefits of this therapy in appropriately selected patients with acute ischemic stroke.