Neurology
RSSArticles
-
Treatment of Progressive Multifocal Leukoencephalopathy
Progressive multifocal leukoencephalopathy, a rare opportunistic viral infection that occurs in patients who have chronic immunosuppression, has defied all attempts at treatment. This observational study, which pooled patient data from multiple centers around the world, showed that there is some benefit using checkpoint inhibitors to help reconstitute the immune system of these patients. However, survival, at best, is 50% of those treated.
-
Long-Term Neurological Outcomes of Patients Treated with CAR-T Therapy
Chimeric antigen receptor (CAR)-T cell therapy is approved for the treatment of lymphoma, leukemia, and multiple myeloma, but its use is associated with early neurotoxicity in almost half of patients. Despite the incidence of neurotoxicity, long-term follow-up of patients after CAR-T infusion suggests that patients’ neurological examination, neuro-imaging studies, and cognition remain unaffected by this treatment.
-
Cerebral Embolic Protection Device Disappoints in TAVR/Stroke Trial
In this largest-to-date randomized trial of stroke prevention in transcatheter aortic valve replacement patients, use of the Sentinel cerebral embolic protection device did not significantly affect the incidence of periprocedural stroke.
-
Informed Consent Requirements May Hinder Innovation in Stroke Treatments
IRBs and regulatory bodies should consider the changing scope of acute stroke care, and collaborate with investigators to design studies that can ethically answer important questions and allow innovation and progress in the field.
-
Poor Cardiovascular Health a Predictor for Premature Brain Aging
Worse cardiovascular health at age 36 years can predict worse brain aging and associated cognitive problems later in life.
-
Epilepsy: The Hidden Side Effect of Bariatric Surgery
The benefits of weight loss procedures are numerous, but a recently published paper reveals a long-term side effect clinicians and patients should heed.
-
Preventing Strokes After Transcatheter Aortic Valve Replacement
Researchers continue testing cerebral embolic protection devices as a solution — but are they effective?
-
Keep on the Sunny Side: Timing Meals for Better Mental Health
Feelings of anxiety and depression can fluctuate depending on when one eats throughout the day.
-
Expert Panel Debunks Common Sleep-Related Myths
Authors identified and deconstructed 10 misconceptions parents hold about teenage nocturnal patterns.
-
Improvement of Memory with Transcranial Electrical Brain Stimulation in Patients with Alzheimer’s Disease
The authors showed that gamma frequency transcranial alternating current stimulation targeting the precuneus in patients with Alzheimer’s disease improved measures of immediate and delayed verbal memory as well as associative memory for faces. Additionally, neurophysiological measurements of cholinergic transmission improved. Apolipoprotein E genotype and baseline cognitive performance were correlated with treatment response. Memory improvement was correlated both with increases in gamma frequency power in posterior cortical regions and spatial overlap between the modeled electric field distribution and the precuneus target site.