Neurology
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Spontaneous Subarachnoid Hemorrhage
This article reviews the typical and atypical presentations of spontaneous subarachnoid hemorrhage and its complications. It also will discuss management of spontaneous subarachnoid hemorrhage and its complications, with a focus on treatment in the emergency setting.
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Cerebral Amyloid Angiopathy and Brain Hemorrhage
When comparing the time course of hematoma expansion between deep hematomas and lobar hematomas from cerebral amyloid angiopathy (CAA) and other etiologies, lobar hematomas from CAA show greater expansion and a longer period of risk for hematoma growth compared to deep hematomas.
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Brain Iron Chelation with Deferiprone in Parkinson’s Disease
In a randomized, placebo-controlled treatment trial, deferiprone administered to early, levodopa-naive Parkinson’s disease patients over 36 weeks was associated with worsening of their symptoms, in spite of imaging evidence for reduction of iron in the substantia nigra.
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Body Weight Decline in Cognitively Intact Older Adults May Predict Future Cognitive Impairment
Among cognitively intact individuals, those who develop mild cognitive impairment (MCI) had faster body mass index (BMI) decline and significantly lower BMI seven years before MCI diagnosis. However, after MCI diagnosis, there was no difference in BMI decline between patients who developed dementia and those who did not.
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What Is Oculopharyngodistal Myopathy?
Distal limb myopathies are rare disorders and are difficult to diagnose. Current muscle biopsy technology, coupled with genetic analysis, offers the best hope for an accurate diagnosis of these unusual neuromuscular disorders. Unfortunately, treatments remain elusive.
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Misdiagnosis of Autoimmune Encephalitis
A recent multicenter, retrospective review of 393 adult patients given a diagnosis of autoimmune encephalitis noted that 107 patients (27%) were misdiagnosed and ultimately had other diagnoses confirmed, but after a considerable delay.
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Long-Term Statin Use Associated with Lower Stroke Risk
A cohort of Danish patients who were taking the cholesterol control medication were less likely to experience an intracerebral hemorrhage.
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Can Artificial Intelligence Help Us to Choose the Best Anti-Seizure Medicine?
A new deep learning artificial intelligence algorithm was able to identify the most effective initial drug to treat newly diagnosed epilepsy, compared to the physicians’ clinical judgment. The algorithm required prospective, carefully collected clinical data for its success.
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Lipid Pathway Dysfunction in Parkinson’s Disease
In this large-scale study, the authors used a comprehensive untargeted lipidomic approach to determine the extent to which lipid dysregulation occurs in patients with Parkinson’s disease generally and in mutation carriers of one of the most common Parkinson’s disease risk genes, LRRK2. Further pathway analysis reveals sphingolipid metabolism, insulin signaling, and mitochondrial function as major metabolic pathways dysregulated in Parkinson’s disease.
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Influence of Vitamin Intake on the Prevalence of Migraine
In a large population-based survey, 21.6% of participants reported having severe headaches or migraine. Those reporting severe headaches also reported a lower intake of thiamine and riboflavin, based on 24-hour recall of food intake. There also was an inverse relationship between thiamine intake and reports of severe headaches.