Neurology
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Alirocumab Injection (Praluent)
Alirocumab provides a new mechanism of action for lowering cholesterol in patients who have not achieved adequate lowering on maximum dose of statins.
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Migraine and Cognitive Dysfunction
During an attack of migraine without aura, patients may experience transient cognitive impairment, with predominant involvement of verbal processing speed, learning, and memory, due to reversible cortical dysfunction.
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Is Low Testosterone Therapy Worth the Hype in the Elderly?
Testosterone replacement therapy showed no impact on subclinical atherosclerosis progression in recent study.
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SGLT2 Inhibitors: Now The Bad News
Sodium-glucose cotransporter-2 inhibitors are approved as adjunctive therapy for the treatment of patients with type 2 diabetes. This drug class has been also used off-label to improve glycemic control in patients with type 1 diabetes.
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ECG Review: Is There Complete AV Block?
The simultaneously-recorded 3-lead rhythm strip in the figure was obtained from a 75-year-old woman who presented to the emergency department with syncope. She was diagnosed as being in complete (third-degree) AV block. Do you agree with this interpretation?
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Clinical Briefs
Treating symptomatic venous thromboembolism with warfarin; extending the window of anticoagulation after pulmonary embolus; and stroke accelerates long-term process of cognitive decline.
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Sacubitril and Valsartan Tablets (Entresto)
A new option for heart failure incorporates two drugs with different mechanisms of action.
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Antibiotics for Acute Appendicitis
A randomized, multicenter clinical trial compared antibiotic therapy to surgery for uncomplicated acute appendicitis and found most patients who received antibiotics did not require appendectomy during the 1-year follow-up period.
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Are Premature Ventricular Contractions Dangerous?
A higher frequency of premature ventricular contractions was associated with a decrease in left ventricular ejection fraction, an increase in incident congestive heart failure, and an increase in mortality.
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The Spice of (Prolonged) Life
ABSTRACT & COMMENTARY: Habitual consumption of spicy foods is associated with reduced mortality independent of other risk factors for death. Hot stuff!