Neurology
RSSArticles
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ECG Review: A 43-Year-Old Man with Atypical Chest Pain
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Clinical Briefs
In this section: reversing the anticoagulant effect of dabigatran; considering the likelihood of occult cancer causing unprovoked deep venous thrombosis; and cardiovascular autonomic neuropathy occurs earlier in type 2 diabetes.
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Evolocumab Injection (Repatha)
Evolocumab is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease in patients who require additional lowering of LDL-C.
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Vitamin D and Diabetic Neuropathy
Vitamin D deficiency may exacerbate the clinical manifestations of diabetic neuropathy, and supplementation with vitamin D3 may be beneficial.
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Nutrition Therapy for Hypertension Using the Nitric Oxide Pathway
Daily one-time ingestion of inorganic nitrate from beet juice consistently lowered blood pressure in hypertensive patients by an amount comparable to single-drug therapy.
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Intensification of Oral Therapy for Type 2 Diabetes
ABSTRACT & COMMENTARY: It may not be relevant to primary care physicians. Here's why.
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Biomarkers of Intrathecal Inflammation in Multiple Sclerosis and Other Disorders
A study of intrathecal immune markers in neuro-immunological diseases revealed increased numbers of activated T and B cells in both relapsing and progressive multiple sclerosis, but they were preferentially embedded in the brain tissue in progressive multiple sclerosis.
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Cerebrospinal Fluid Tau and Amyloid-ß1-42 in Patients with Dementia
In patients with clinically diagnosed dementia, the CSF biomarker profile of low CSF amyloid-ß1-42, high total tau, and high phosphorylated tau was seen in the majority of patients with clinically diagnosed Alzheimer’s disease. Substantial proportions of patients with non-Alzheimer’s dementia were also found to have the Alzheimer’s disease pathological profile. The value of CSF biomarker measurements in clinical practice is uncertain.
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Vitamin D and Diabetic Neuropathy
Vitamin D deficiency may exacerbate the clinical manifestations of diabetic neuropathy, and supplementation with vitamin D3 may be beneficial.
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The Expanding Role of Tau in Neurodegeneration: New Insights from Huntington’s Disease
Although Huntington’s disease is due to a triplet repeat expansion in the huntingtin gene, this study demonstrates abnormally phosphorylated tau pathology in Huntington’s disease brain tissue.