Neurology
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Tenofovir Alafenamide vs Tenofovir Disoproxil Fumarate
Tenofovir alafenamide has replaced the tenofovir disoproxil fumarate component of two commonly used drug combinations for HIV-1 infection.
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ICH May Clinically Mimic TIA
In a large retrospective review of 2137 patients with intracerebral hemorrhage, 34 presented with transient symptoms that could have been misclassified as “transient ischemic attack” if brain imaging had not been performed.
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Selecting Patients for Statin Primary Prevention
The new vascular disease risk calculator discriminates who will experience a vascular event in the near future better than using a trial entry criteria approach or a hybrid approach.
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Is Anticoagulant Bridging Needed in Patients with Atrial Fibrillation Going to Surgery?
In patients with atrial fibrillation who had warfarin treatment interrupted for an elective operation or other elective invasive procedure, forgoing bridging anticoagulation was not inferior to perioperative bridging with low molecular weight heparin for the prevention of arterial thromboembolism and decreased the risk of major bleeding.
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Potatoes Increase Risk of Type 2 Diabetes Mellitus
Few would question the recommendation to increase daily vegetable intake. Yet, an important question arises — are all vegetables created equal?
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Why We Can’t Allow Physical Exam Skills to Languish
With more highly evolved and readily available technology at our fingertips, it is sometimes tempting to let the echocardiogram sort out the abnormal heart sounds we detected, or allow the pelvic ultrasound to inform whether the uterus is enlarged, or short-cut parts of the physical exam we anticipate to be unlikely sources of pertinent information.
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Nitrate Therapy Shows Possible Harm in Heart Failure with Preserved Ejection Fraction
In heart failure with preserved ejection fraction, the use of isosorbide mononitrate was associated with a nonsignificant decrease in physical activity level, and no improvement in symptoms or quality of life.
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Does Finding the Portal of Entry of Bacteria in Infective Endocarditis Matter?
A comprehensive, systematic search for the portal of bacterial entry in infective endocarditis is frequently successful and affords an opportunity to prevent recurrent episodes.
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Does the Use of Saline vs Buffered Crystalloid Reduce Risk of Acute Kidney Injury in ICU?
The use of a buffered crystalloid compared with saline did not reduce the risk of acute kidney injury in patients receiving crystalloid fluid therapy in the ICU.
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Effects of a Rapid Response System Driven by Real-time Automated Clinical Alerts
The addition of an automated real-time clinical deterioration alert system to a rapid response system had marginal effects.