Neurology
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Carpal Tunnel Syndrome: Everything You Want To Know, and More
Carpal tunnel syndrome can be reliably diagnosed, only with nerve conduction studies, and this test should be performed before any invasive treatments are initiated.
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Relationship Between Spikes and Seizures Using an Implantable Intracranial Detection Device
The authors report the preliminary findings for an implantable ambulatory intracranial recording device for seizure detection in 15 subjects. One of the primary findings was that spike rate significantly changed prior to seizures in nine of 15 subjects. Six of these subjects showed a significant decrease in spiking prior to ictal onset, whereas the remaining three showed a significant increase in spiking and these three subjects had the best seizure prediction results.
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Clinical Characterization of Inherited Erythromelalgia Due to Sodium Channel Mutations
A detailed non-interventional clinical study of patients with inherited erythromelalgia who carry gain-of-function mutations of voltage-gated sodium channel Nav1.7 further characterized pain phenotypes in this disorder and showed wide variability of pain symptoms.
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Clinical Briefs
In this section: examining autoimmune disorders associated with vitiligo; moderate alcohol consumption is not associated with reduced all-cause mortality; and rethinking the American diet.
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Ixekizumab Injection (Taltz)
Ixekizumab is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
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Outcome of PCSK9 Inhibitor-treated Patients
In a meta-analysis of 17 studies, proprotein convertase subtilisin-kexin type 9 serine protease inhibitors markedly reduced low-density lipoprotein cholesterol levels and all-cause mortality, but was associated with a significant increase in neurocognitive adverse events.
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Menopausal Hormone Therapy: Useful and Indicated for Vasomotor Symptoms
Menopausal hormone therapy is the most effective treatment for symptoms of the menopause, and benefits may exceed risks for most women within 10 years of menopause.
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Drug-resistant Hypertension? Consider Adding a Nonpharmacologic Prescription
In patients with obstructive sleep apnea and hypertension, continuous positive airway pressure use was associated with clinically and statistically significant reductions in blood pressure for both resistant and non-resistant hypertension.
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Chest Pain and Giant T Wave Inversion
Chest pain (rather than shortness of breath) and ST elevation (rather than T wave inversion) in leads V1 and V2 make massive pulmonary embolism unlikely.
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Clinical Briefs
In this section: the insulin misadministration problem; comparing smoking cessation pharmacotherapies; more support for ambulatory BP monitoring.