Neurology
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Community Education Improves Stroke Awareness and Appropriate Emergency Response
Community education programs are essential in efforts to improve overall success in treating acute ischemic stroke.
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Distinct EEG Features May Help Prognostication of Patients with Early PAMM
Early post-anoxic multifocal myoclonus (PAMM) traditionally has been considered a grave prognostic feature in patients who remain comatose after cardiac arrest. This study defines distinct electrographic phenotypes in the setting of PAMM with substantially different prognostic outcomes.
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Functional MRI in REM Behavior Disorder Is Suggestive of Future Parkinson’s Disease
Rapid eye movement behavior disorder carries an increased risk of future Parkinson’s disease and has fMRI and DaTSCAN features that are similar to those in patients with Parkinson’s disease.
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Association of Traumatic Brain Injury with Late-life Neurodegenerative Diseases
This study analyzed pooled clinical and neuropathological data of older adults free of dementia from three prospective cohort studies and found that traumatic brain injury with loss of consciousness was associated with risk for Lewy body accumulation, Parkinson’s disease, and progression of Parkinsonism, but not dementia, Alzheimer’s disease, neuritic plaques, or neurofibrillary tangles.
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Neuropathy in Myeloma
Peripheral neuropathy is uncommon at presentation in patients with myeloma, and may be complicated by vitamin D deficiency and the neurotoxic effects of chemotherapy.
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Impulse Control Disorders in Parkinson’s: Are All Dopamine Agonists Equal Offenders?
This observational study of 425 patients with a broad range of stages of Parkinson’s disease found that long-acting pramipexole and transdermal rotigotine were less likely to be associated with impulse control disorders than were immediate-release pramipexole and any formulation of ropinirole. This study highlights differences between dopamine agonists that may affect patient care.
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Individualized Integrative Medicine Treatment for Preoperative Anxiety
In a randomized, clinical trial investigating the treatment of preoperative anxiety, standard sedating medication with a specified add-on individualized integrative technique is the most effective intervention.
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How Good Is Passive Leg Raise at Predicting Fluid Responsiveness?
SYNOPSIS: In a meta-analysis of 23 clinical trials, passive leg raise was shown to be an excellent predictor of fluid responsiveness.
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In Patients with Intracerebral Hemorrhage, Intensive Lowering of Blood Pressure Does Not Improve Outcome
After spontaneous intracerebral hemorrhage, there is a severe hypertensive response that may be associated with hematoma expansion and increased mortality. The INERACT-2 study (N Engl J Med 2013;368:2355-2365) looked at the effectiveness of blood pressure reduction within six hours after symptom onset, to a target systolic blood pressure of < 140 mmHg.
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Screening for C. difficile Carriers at Hospital Admission Reduces Subsequent CDI
Hospital patients were screened for C. difficile. Contact isolation led to a significant decrease in hospital-acquired C. difficile infections.