Neurology
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Statins Associated with Lower Parkinson’s Risk in Diabetics
In approximately 50,000 individuals with Parkinson’s disease and diabetes, identified from a National Health Insurance database in Taiwan, statin use was dose-dependently associated with lower risk of Parkinson’s disease.
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Alzheimer’s Disease: What the Primary Care Physician Needs to Know
This article explores current medical approaches to Alzheimer’s dementia, the most common subtype of the known dementias or neurocognitive disorders. Preventive treatment is at the forefront of efforts to defeat this progressively impairing disorder; but to be effective, intervention must start well before symptoms begin. The role of the primary care provider in initiating vigorous and early preventive measures and applying appropriate pharmacologic and non-pharmacologic interventions at each stage of disease progression is reviewed and discussed.
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Why Do the Beats Keep Changing?
What clinical situation commonly is associated with arrhythmias such as the one shown in this figure?
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Adalimumab-atto Injection (Amjevita)
Adalimumab-atto provides an alternative to adalimumab for multiple chronic inflammatory conditions.
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Optimal Blood Pressure in Patients Presenting with Aortic Stenosis
A post-hoc analysis of patients suffering from mild to moderate aortic stenosis in a study of low-density lipoprotein cholesterol lowering showed that the optimal blood pressure for the best survival was 130-139/70-90 mmHg.
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What Should You Tell Your Patients About Sleep Apnea, CPAP, and Heart Disease?
In this large, multicenter, randomized, controlled trial, continuous positive airway pressure did not reduce incident cardiovascular events compared with usual care, but did reduce snoring and daytime sleepiness and improved health-related quality of life and mood.
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Outcomes in Patients Treated with Therapeutic Hypothermia After In-hospital Cardiac Arrest
Current guidelines recommend the use of therapeutic hypothermia in patients with in-hospital cardiac arrest, even though its efficacy has been demonstrated only in randomized trials after out-of-hospital cardiac arrest. This non-randomized, observational cohort study based on a large national registry found that the use of therapeutic hypothermia was associated with lower likelihood of survival and less favorable neurological outcome in patients successfully resuscitated after an in-hospital cardiac arrest.
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Statins Associated with Lower Parkinson’s Risk in Diabetics
In approximately 50,000 individuals with Parkinson’s disease and diabetes, identified from a National Health Insurance database in Taiwan, statin use was dose-dependently associated with lower risk of Parkinson’s disease. This strengthens the argument for a possible protective role of statins.
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Intravenous Glyburide to Reduce Brain Swelling in Large Hemispheric Infarction
In a Phase II, randomized, multicenter prospective trial, intravenous glyburide failed to improve outcomes in patients with large hemispheric infarction, although there was a reduction in neuroimaging and biomarkers of cerebral edema.
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RESCUEicp: A Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension
Decompressive craniectomy for the treatment of refractory intracranial hypertension in patients with severe traumatic brain injury reduced mortality but increased rates of vegetative states, lower severe disability, and upper severe disability compared to continued medical management.