Neurology
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Alzheimer’s Disease Deaths Increased 55% Since 1999
The rate of deaths from Alzheimer’s disease increased 54.5% over 15 years, according to a new CDC report
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Is Exposure to Arterial Hyperoxia During Critical Illness Dangerous?
Exposure to severe hyperoxia during critical illness is associated positively with increased ICU and hospital mortality and associated negatively with ventilator-free days.
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Dementia Updates for Primary Care Providers
The diagnostic criteria for Alzheimer’s disease (AD) have changed in recent years, with a growing focus on pathologic and genetic biomarkers. The diagnosis itself now is divided into three distinct stages: the preclinical stage, mild cognitive impairment, and clinical AD. Dementia is a common and growing problem that is associated with significant caregiver burden and immense cost. A growing focus on disease prevention and management of risk factors in mid-life is vital to attempt to mitigate the daunting impact of this illness on patients, caregivers, and the healthcare system as a whole.
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Consumption of Artificially Sweetened Beverages Increases Stroke Risk
Higher recent and higher cumulative intake of artificially sweetened soft drinks was associated with an increased risk of ischemic stroke and Alzheimer’s disease. However, sugar-sweetened beverage consumption was not associated with stroke or dementia.
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Excellent Outcome 2 Years After Endovascular Mechanical Thrombectomy
The beneficial effects of endovascular treatments on functional outcome at two years in patients with acute ischemic stroke was similar to those reported at 90 days in the original trial.
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Hematopoietic Stem Cell Transplantation for Adult Cerebral X-linked ALD
Based on review of data from 14 patients with adult cerebral X-linked adrenoleukodystrophy who were treated with hematopoietic stem cell transplantation, the authors suggested that this might be an intervention that potentially could have long-term benefits and recommended further studies to evaluate this therapy.
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Spinal Manipulative Therapy for Acute Low Back Pain
Spinal manipulative therapy for acute low back pain may provide some benefit, but carries a significant risk of treatment-associated pain.
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Vascular Risk Factors and Their Role in the Development of Alzheimer’s Disease
This study has found an association between mid-life, but not late-life, vascular risk factors and brain amyloid deposition as imaged on amyloid-labeled PET.
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Serotonin Transporter Increases in Premotor Parkinson’s Disease
In a small cross-sectional study, increased serotonin transporter was detected using 11C-DASB PET in striatum, hypothalamus, and brainstem in LRRK2 carriers who did not have clinical Parkinson’s disease. This contrasts with later decreases previously described and implies a likely early compensatory mechanism.
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Autoimmune Antibodies in Patients with Epilepsy of Unknown Etiology
In this prospective study of patients with epilepsy of unknown origin (including new-onset and established epilepsy), more than 20% of patients were found to have neurological autoantibodies strongly suggesting autoimmune origin of their epilepsy.