Neurology
RSSArticles
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Tacrolimus for Treatment of Myasthenia Gravis
A large observational study performed in Korea suggests that tacrolimus is an effective immunomodulating, steroid-sparing medication for the treatment of myasthenia gravis.
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Prediction of Survival After Cardiac Arrest Using Pupillometry
Automated infrared pupillometry holds promise as a quantitative, reproducible measure that aids in determining neurological prognosis after cardiac arrest and coma.
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Distinguishing Ischemic from Non-ischemic Cardiomyopathy Clinically
SYNOPSIS: This cardiac catheterization-based study of patients with newly diagnosed reduced left ventricular ejection fraction of unknown etiology showed that 15% had ischemic cardiomyopathy and they could be identified by clinical characteristics and an ECG-based risk score.
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B-type Natriuretic Peptide Is Less Useful in Elderly Patients with Dyspnea
SYNOPSIS: Among patients ≥ 80 years of age presenting with acute dyspnea, B-type natriuretic peptide level was not useful for differentiating cardiac vs. respiratory etiologies when added to a model of clinical predictors.
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Sepsis Management: What We Think We Know
SYNOPSIS: In the Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM), 3,723 patients’ outcomes from the ProCESS, ARISE, and ProMISe randomized, controlled trials of early goal-directed therapy (EGDT) were evaluated. EGDT did not result in better outcomes than usual care and was associated with higher costs. The authors of a second study looked at outcomes of 49,331 patients with sepsis treated in New York from April 2014 to June 2016. More rapid completion of the three-hour sepsis bundle and antibiotic administration (but not rapid bolus administration of IV fluids) was associated with reduced in-hospital mortality.
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Dual Antibiotic Therapy Is Not Routinely Necessary for Uncomplicated Cellulitis
SYNOPSIS: A randomized, multicenter, placebo-controlled clinical trial that enrolled patients presenting to emergency departments with uncomplicated cellulitis found the addition of trimethoprim-sulfamethoxazole to cephalexin did not lead to better outcomes.
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Clinical Briefs
In this section: Use caution with a nocturia treatment; an analysis of a cellulitis remedy; and handling influenza patients.
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Sarilumab Injection (Kevzara)
Sarilumab is indicated for the treatment of adults with moderately to severely active rheumatoid arthritis who have demonstrated an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs.
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Possible Benefit From Pharmaceutical-grade Chondroitin on Knee Osteoarthritis
The authors of a European study found a statistically significant and clinically marginally significant reduction in pain at three and six months in patients taking pharmaceutical-grade chondroitin sulfate for knee osteoarthritis.
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Glucose Self-monitoring May Not Be That Useful
Researchers could not find any statistically significant differences in glycemic control or health-related quality of life between patients who performed glucose self-monitoring compared with those who did not.