Neurology
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Clinical Briefs
In this section: nonsteroidal anti-inflammatory drugs and gastrointestinal bleeding; rheumatoid arthritis; and community-acquired pneumonia.
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Delafloxacin Tablets (Baxdela)
Delafloxacin is indicated for the treatment of acute bacterial skin and skin structure infections caused by susceptible organisms.
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Atypical Transient Symptoms Require Aggressive Investigation for Cause
Atypical transient symptoms, such as partial sensory deficit, dysarthria, vertigo and unsteadiness, unusual visual deficits, and diplopia, usually are not classified as transient ischemic attacks, and they frequently are not investigated in the same fashion.
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Glycemic Measures May Vary Depending on Race
In patients with type 1 diabetes, hemoglobin A1c levels overestimate the mean glucose concentration in black persons compared with white persons, possibly owing to racial differences in the glycation of hemoglobin.
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Long-term Use of Proton Pump Inhibitors and Earlier Death
An observational study of a Veterans Affairs population showed that the use of proton pump inhibitors over a median 5.7-year follow-up period increased the risk of death by 25% compared with the use of histamine 2 blockers or no medication.
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Saffron and Depression: What Do We Know and Where Do We Go?
Saffron studies, while still preliminary, show potential for use of this ancient spice in combatting mild-moderate depression.
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Treatment of Intracerebral Hemorrhage Guided by the ‘Spot Sign’
Although the “spot sign” is a predictor of early hematoma expansion, selective treatment of this group with aggressive antihypertensive therapy did not alter hematoma size or neurological outcome.
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Direct DNA Sequencing of Dominant Cerebellar Ataxias
Current genetic testing techniques with DNA sequencing can diagnose the molecular-genetic causes for the majority of dominantly inherited cerebellar ataxias.
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Severe Olfactory Impairment Is Associated With Preclinical Alzheimer’s Disease
In this cross-sectional, population-based, cohort study of 829 cognitively normal participants, abnormal neuroimaging biomarkers known to be associated with Alzheimer’s disease were associated with severe olfactory impairment.
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Plasma α-Synuclein Is a Leading Candidate Biomarker in Parkinson’s Disease
In this cross-sectional study, plasma alpha-synuclein levels were higher in individuals with Parkinson’s disease than controls, and correlated with cognitive decline.