Neurology
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Maternal Mortality, Postpartum Hemorrhage, and Tranexamic Acid: The WOMAN Study
SYNOPSIS: A multicenter study involving patients in 193 countries has shown a decrease in maternal mortality in women with postpartum hemorrhage who were given tranexamic acid once the diagnosis was made.
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Requiem for Beta-blockers Post-Myocardial Infarction?
SYNOPSIS: A propensity score analysis of all hospital survivors of acute myocardial infarction in the United Kingdom from 2007-2013 showed that one-year survival in hospital patients without heart failure or left ventricular dysfunction treated with beta-blockers did not differ from survival in those patients not so treated.
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Early Diuretic Administration Associated With Improved Survival in Acute Heart Failure Patients
SYNOPSIS: Among patients presenting to the ED with acute heart failure, those who received the first dose of intravenous furosemide within 60 minutes of arrival demonstrated lower in-hospital mortality compared to those receiving the first dose after 60 minutes.
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Cefazolin Leads to Better Outcomes for Methicillin-susceptible Staphylococcus aureus Bacteremia Than Nafcillin or Oxacillin
SYNOPSIS: A retrospective study that included patients from 119 Veterans Affairs hospitals found lower mortality and a similar recurrence rate for methicillin-susceptible Staphylococcus aureus bacteremia treated with cefazolin compared to nafcillin and oxacillin.
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Clinical Briefs
In this section: blood pressure readings for high-risk hypertension patients; Omega-3 fatty acids and diabetic retinopathy; and long-term diabetes control.
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Betrixaban Capsules (Bevyxxa)
Betrixaban is indicated for the prophylaxis of venous thromboembolism (VTE) in adult patients hospitalized for an acute medical illness who are at risk for thromboembolic complications because of moderate or severe restricted mobility and other risk factors for VTE.
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Omega-3 Polyunsaturated Fatty Acid Supplementation and Cognitive Decline
As the first large randomized, placebo-controlled trial studying the efficacy of a lifestyle intervention with a nutraceutical compound (polyunsaturated fatty acid), the Multidomain Alzheimer Preventive Trial is a landmark study.
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B-type Natriuretic Peptide Is Less Useful in Elderly Patients With Dyspnea
Among patients ≥ 80 years of age presenting with acute dyspnea, B-type natriuretic peptide level was not useful for differentiating cardiac vs. respiratory etiologies when added to a model of clinical predictors.
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Advance Care Planning Must Advance Forward
Advance care planning is a continual process of preparing for future medical care in case patients are unable to make his or her own decisions. It includes engaging patients and families to reflect on patients’ personal goals, values, and belief systems, which ultimately translate into informing medical care. This process helps prepare the patient for current and future decisions regarding medical treatment. Data show that Americans have fallen behind on this process.
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Atrial Flutter or Atrial Tachycardia?