Neurology
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What Is the Ideal Target for Blood Pressure Control?
Patient-reported outcomes in a recent trial of subjects who received intensive treatment with a target systolic blood pressure of < 120 mmHg were similar to those who received standard care, supporting the recommendations of SPRINT.
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Cerebrolysin Is Unproven as a Neuroprotectant for Acute Ischemic Stroke
The routine use of Cerebrolysin in acute stroke is not justified.
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Idarucizumab for Reversal of the Anticoagulant Effects of Dabigatran
The administration of idarucizumab is effective and safe for the reversal of the direct thrombin inhibitor, dabigatran, and should be used in appropriate clinical situations.
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Sudden Prehospital Death From Subarachnoid Hemorrhage
Based on recent nationwide data reported from Finland, one-fourth of those experiencing their first ever subarachnoid hemorrhage died suddenly before being admitted to a hospital.
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Polyneuropathy and Nutrition
Other than the identification of a specific vitamin or essential element deficiency, overall nutritional status does not appear to play any role in the development of idiopathic neuropathies in adults.
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Lamotrigine for Myotonia
SYNOPSIS: In a randomized, double-blind, placebo-controlled treatment trial of patients with non-dystrophic myotonia, those treated with lamotrigine experienced significant improvement.
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REM Sleep, Not Slow-wave Sleep, Decreases Dementia Risk
In a series of clinical studies of cognitively normal people older than 60 years of age, disruption of REM sleep and reduced quantity of REM sleep increased the risk of developing Alzheimer-type dementia.
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Tau as a Biomarker of Acute and Chronic Traumatic Brain Injury
The ongoing search for reliable biomarkers of traumatic brain injury repeatedly has demonstrated the reliability of using plasma phosphor-tau levels to help distinguish injury from normal, and severe injury from mild injury.
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Taste, Smell, and the Insular Cortex
Olfaction and taste appear to be localized in the insular cortex with bilateral representation.
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Functional Outcomes After Receiving Life-sustaining Therapy in the ICU
Among patients who have spent at least three days in an ICU and required even brief mechanical ventilation and/or vasopressor support, almost half are dead and only one-third return to their baseline at six months. Several factors present on the first day of admission are associated with not returning to baseline status.