Visual hallucinations and delusions are common in patients with moderate to advanced Parkinsons disease (PD). Typically fleeting images of people, children, or animals are easily ignored; however, hallucinations often become more intense and frequent, with loss of insight.
In this simple yet elegant, single-blind, placebo-controlled, crossover study, 12 patients with McArdles disease were given a sucrose, or artificially sweetened placebo load, prior to aerobic exercise to determine if this might improve exercise tolerance. Average age of the 7 men and 5 women was 37 years, and all had lifelong exercise intolerance, episodic muscle cramps, and myoglobinuria triggered by exercise.
