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Men and women with restless legs syndrome (RLS), aged 18-79 years, were included in this randomized, 12-week, double-blind, placebo-controlled study conducted at 43 centers in 10 European countries, designed to assess the efficacy of ropinirole, a dopamine agonist, in the treatment of RLS. Ropinirole significantly improved IRLSSG score at 12 weeks compared to placebo, with benefit evident even at week 1.
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This report described the results of a double-blind, placebo-controlled study of flupirtine maleate (FLU), a triaminopyridine compound in patients with Creutzfeldt-Jakob disease (CJD). The patients with flupirtine showed significantly less deterioration in the dementia tests than the patients treated with placebo.
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The prospects for therapy in Huntingtons disease are rapidly improving. Another potential treatment is to use striatal neural grafts.
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The availability of comprehensive records of public health in Scandinavian countries is a major advantage in working out epidemiological studies. The present study of Swedish twins including many older than 80 now suggests that the genetic component of AD may be less than previously thought.
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What characteristics of a neuropathy make Sjögren syndrome the likely diagnosis?
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In an entirely novel observation, Walz and associates describe a cellular prion protein variant associated with hippocampal sclerosis that seems to be partially predictive of seizure-free outcome in patients undergoing surgery for medically refractory mesial temporal lobe epilepsy.
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In this epidemiologic analysis of 22,312 individuals living in Norway, a total of 87 reported having developed multiple sclerosis. The risk of developing multiple sclerosis was significantly higher among smokers than among never-smokers.
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Economy class syndrome (ECS) refers to venous thromboembolic episodes among airline passengers who have remained immobile for long periods in cramped seating that impairs their circulation. Economy class passengers with little leg space are more likely to suffer such events than passengers in roomy first-class seats.
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In this second part of our two-part series, the SCMARTI (Selection of Cephalosporins, Macrolides, and AFQs for Respiratory Tract Infections) Consensus Panel presents recommendations for antimicrobial therapy in acute bacterial exacerbations of chronic bronchitis, along with a comprehensive treatment table to guide therapy in the emergency department and outpatient setting.
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Many therapeutic options now are available to prevent and treat osteoporosis, and consist of non-drug and drug or hormonal therapy. In just one decade, osteoporosis has been transformed from a disorder considered to be an inevitable and irreversible consequence of aging to a disorder in which there now is true therapeutic optimism. This article discusses the definition, epidemiology, and different causes of osteoporosis. Diagnostic studies, including bone densitometry, are reviewed as well as the various therapies.
