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As discussed previously in Neurology Alert, there is increasing evidence that a number of dietary manipulations may significantly affect the risk of dementia and Alzheimers disease (AD). Three studies in 2002 indicated that dietary intake of vitamins E and C lowered the risk of getting AD. However, there appeared to be no association with intake from dietary supplements. This is an important point since it is much easier to take dietary supplements than to increase ones dietary intake of antioxidant vitamins.
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Huntingtons disease is a progressive neurodegenerative disease with onset generally in midlife. Insoluble huntingtin protein aggregates have been seen in vitro in mammalian cells, as well as in transgenic mouse models and in brain tissues from patients with Huntingtons disease. The relationship between the presence of the insoluble protein aggregates and Huntingtons disease pathogenesis has been controversial.
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Chronic inflammation is now a well-recognized cause of atherosclerotic vascular disease, including coronary artery disease and stroke. Asymptomatic individuals harboring the common bacterium Chlamydia pneumoniae have been shown to have an elevated incidence of plaque in both the coronary and carotid arteries.
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Approximately 10% of all patients with middle cerebral artery (MCA) territory cerebral infarction suffer progressive deterioration due to cerebral edema, increased intracranial pressure, and brain herniation. In these patients with malignant MCA territory infarction aggressive decompressive craniectomy has been reported to improve overall prognosis.
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How does one physiologically explain ulnar neuropathies at the elbow that clinically localize to the wrist? Why do proximal sciatic neuropathies sometimes masquerade clinically as peroneal neuropathies at the knee? In this lucid, well-articulated review, Stewart thoroughly and evenhandedly comments on the literature going back to 1913, convincingly arguing that nerve fibers do not randomly intertwine as they progress distally in nerve bundles.
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The FDA has approved the first combination NSAID and proton pump inhibitor.
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Numerous published studies have strongly suggested that negative emotions such as depression and anxiety contribute to the development of symptomatic coronary artery heart disease.
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Gastric fundic gland polyps can be visually horrifying when seen on endoscopy, and they are now quite commonly present in patients taking chronic acid suppressive therapy with proton pump inhibitors.
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It has been estimated that as many as 50% of hospitalized congestive heart failure patients are malnourished.
