Neurology
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Blockade of CGRP for Migraine Prevention: Promising, but Not a Cure
Blockade of calcitonin gene-related peptide in patients with chronic or episodic migraine results in the prevention of about two headache days a month compared to placebo.
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Obesity Is a Hormonal Illness
Once obese, a patient’s metabolism adapts with insulin resistance to maintain body fat. High insulin levels promote fat storage and block fat burning.
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Serum Tau as a Reliable Biomarker of Outcome After Cardiac Arrest
Currently, there are no reliable and readily available biomarkers to assist in determining prognosis for neurological recovery after cardiac arrest, but serum tau measurements hold promise for the future.
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Pain in Anti-MAG Neuropathy
Most patients with anti-MAG neuropathy complain of painful paresthesias or dysesthesias, but unlike diabetic neuropathy, these symptoms are not severe and do not affect quality of life as much as motor weakness.
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Myasthenia Gravis, MuSK, and Pregnancy
Myasthenia gravis increases both maternal and fetal complications and mortality during pregnancy, but the MuSK-antibody variant appears less morbid, based on this small retrospective series of 17 patients.
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Functional Imaging Studies in Parkinson’s Disease
A meta-analysis of 142 studies demonstrated that functional imaging studies in Parkinson’s disease using tracers for aromatic acid decarboxylase showed smaller defects compared to those using tracers targeting dopamine transport and VMAT2. Symptom severity correlated linearly with dopamine neuron loss as determined by these imaging studies.
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Targeting Hypersensitive Corticostriatal Terminals to Treat Restless Legs Syndrome
SYNOPSIS: Based on this innovative study using optogenetic microdialysis, the mechanisms underlying restless legs syndrome include dopamine-mediated hypersensitivity of corticostriatal neurons to glutamate release.
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Neuroimmunology and Movement Disorders: When Should We Test for Autoantibodies?
Autoantibody-associated neurological disorders can mimic neurodegenerative and other movement disorders, but are likely under-diagnosed, resulting in missed treatment opportunities. This review is a “must read” for all neurologists.
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Lifestyle Approaches to Prevent and Manage Cognitive Impairment
Despite billions of dollars in research and nearly 200 medications tested for dementia, pharmacologic treatment for Alzheimer’s disease is severely limited in effectiveness and safety. With the disappointing benefits of drug treatment, the promise of lifestyle changes to prevent and delay cognitive decline appears hopeful.