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A large, multicenter clinical trial that compared protocol-based care to usual care for patients presenting to emergency departments with early sepsis and septic shock found no differences in clinical outcomes. However, early recognition and therapy was beneficial and should be the standard of care.
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Compared to manual surveillance methods, an electronic surveillance tool for catheter-associated urinary tract infections had a high negative predictive value but a low positive predictive value.
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Patients on mechanical ventilation who were managed with both conservative fluid administration and aggressive diuresis weaned faster, had significantly more ventilator-free days, and experienced reduced incidences of both ventilator-associated complications and ventilator-associated pneumonia.
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During my final year of interventional cardiology training, a woman in her 60s was brought emergently to the cath lab in cardiogenic shock, with diffuse ST-segment elevations.
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In a systematic review and meta-analysis of prospective studies examining the association between mental stress-induced myocardial ischemia (MSIMI) and adverse outcome events in patients with stable CAD, all existing investigations point to an approximate doubling of cardiovascular risk in patients with MSIMI.
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The first in a new class of orexin receptor antagonists has been approved by the FDA for the treatment of insomnia. Orexins are hypothalamic neuropeptides that appear to have a role in maintaining wakefulness.
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The American College of Physicians recommends against performing screening pelvic examination in asymptomatic, nonpregnant, adult women.
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Detecting HIV early creates opportunity for treatment and reduces transmission risk.
