Neurology
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Planes, Pathogens, and Passengers: Infection Risk During Commercial Air Travel
Although air travel has been linked to transmission of respiratory infections, the actual risk of becoming infected during air travel is low. The risk is greatest, though, when seated within about two seats/rows of a contagious individual. Walking around the cabin increases the risk.
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Risk of Endocarditis Revisited
The authors of a population-wide study of hospitalizations and deaths from infective endocarditis (IE) in England confirmed the high risk of IE in certain cardiac conditions, but showed that other conditions thought to be low risk also are at higher risk and found new higher-risk categories not previously identified.
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Acute Pericarditis or Something Else?
Does the ECG included with this article suggest either acute pericarditis or acute infarction? What key piece of information is missing from the history? How would you interpret the tracing?
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Tolvaptan Tablets (JYNARQUE)
Tolvaptan is indicated to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease.
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Rapid Screening for Future Risk of Parkinson’s Disease Dementia
The Montreal Parkinson Risk of Dementia Scale provides a simple eight-item screening tool with high predictive value for developing Parkinson’s disease dementia.
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Combined Treatments with Medications for Hypertension and Hyperlipidemia Dramatically Reduce the Risk of Stroke
In this real-world study, fixed-dose candesartan/hydrochlorothiazide combined with low-dose rosuvastatin reduced first stroke by 44% in patients at intermediate risk of cardiovascular disease and was well tolerated, with minimum dropout of patients.
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Chiropractic Spinal Manipulation for Migraine
Chiropractic spinal manipulation offers no benefit over placebo for migraineurs.
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The Pulmonary Embolism Rule-out Criteria in Low-risk Patients
A cluster randomized trial of the pulmonary embolism rule-out criteria (PERC) compared to usual care for patients estimated to be at low risk of pulmonary embolus (PE) in EDs showed that PERC was non-inferior to usual care at identifying patients who would be free of symptomatic PE at three months, resulting in less use of healthcare resources.
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Anti-MAG Antibodies: Clinical and Therapeutic Aspects
Anti-MAG antibody-associated neuropathy may present as many disorders, including small fiber neuropathy, sensorimotor neuropathy, Guillain-Barré-like syndrome, and multifocal motor neuropathy. Rituximab appears to be the best therapeutic option.
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Longitudinal tau PET as an Outcome Measure for Clinical Trials
tau PET imaging shows progression of brain Alzheimer’s pathology over time and correlates with cognitive impairment better than amyloid PET. In future clinical trials, tau PET can serve as a biomarker for Alzheimer’s disease progression.