Neurology
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Runs of VT, or Aberrant Conduction?
A 47-year-old man presented with a history of intermittent dizziness over the previous two days. He was hemodynamically stable at the time the ECG in the figure was obtained. How would you interpret the rhythm? Is there any clue to a possible etiology for this patient’s arrhythmia?
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Plazomicin Injection (Zemdri)
Plazomicin is indicated for the treatment of adults ≥ 18 years of age with complicated urinary tract infections.
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Sepsis-related Neurologic Dysfunction Strongly Associated With Long-term Mortality
In this multicenter, retrospective study, acute neurologic dysfunction was the organ dysfunction most strongly associated with short- and long-term mortality in patients surviving a sepsis hospitalization.
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Worse Than Snake Oil
Rattlesnake “pills” are basically dehydrated, ground up rattlesnake meat stuffed into gel caps. These may be sold locally in health food stores and are available online. The FDA has not reviewed nor approved this item.
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Invasive Procedures and the Risk of Infective Endocarditis
This large study suggests that several invasive, nondental medical procedures may be triggers for subsequent infective endocarditis, reopening the debate regarding prevention and management.
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Does Triple Inhaled Therapy for COPD Decrease Exacerbations Compared to Dual Therapy?
A single dose of inhaled triple therapy improved exacerbations compared to dual therapy in COPD patients.
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Untangling the Factors Governing Huntington’s Disease Progression
In a study of more than 3,000 subjects, CAG-repeat-dependent factors affecting age at onset also influenced rates of progression of cognitive, motor, and functional impairments, providing optimism that developing interventions, such as gene silencing therapies, could provide benefit.
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Predicting Future Dementia With Retinal Optical Coherence Tomography
Optical coherence tomography (OCT) is an innovative imaging device that measures thickness of retinal nerve fiber layers and ganglion cells. Thinning of these layers is associated with current and future risk of dementia.
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Use of Amyloid PET Imaging for Diagnosis of Dementia
The use of amyloid positron emission tomography scanning to assist in accurate diagnosis of patients with symptoms of cognitive impairment as well as frank dementia results in a change of diagnosis in at least 25% of patients.
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Viral Therapy for Glioblastoma
In a Phase I/II trial, convection-enhanced delivery of an engineered poliovirus yielded similar median overall survival compared to historical controls. However, a small subgroup of treated patients had extended survival past two years.