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Ten risk factors are associated with approximately 90% of ischemic and hemorrhagic strokes. Hypertension, smoking, abdominal obesity, physical inactivity, and diet are the most important modifiable risk factors for stroke.
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In a cohort of patients presenting with acute myelitis, motor onset and a subsequent relapse were the strongest predictors of residual disability. An abnormal baseline brain MRI was the strongest predictor for conversion to multiple sclerosis.
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Obstructive sleep apnea causes a variety of alterations in the control of cerebral blood flow, contributing to the risk for stroke.
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Confocal microscopy of the cornea may be a useful diagnostic test to identify patients with small-fiber neuropathies.
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Concern about serotonin syndrome should not prevent migraineurs who have mood disorders from being treated judiciously with the combination of triptans and serotonergic medications.
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A great debate continues regarding appropriate management of hypertension during acute stroke. In the U.S., permissive hypertension is popular with recommendations that antihypertensive medications be discontinued when an acute ischemic stroke occurs.
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Lorcaserin submitted for FDA review, FDA advisory panel votes against phentermine/topiramate, mixed vote on rosiglitazone, advisory panel votes to remove breast cancer indication from bevacizumab labeling, no increase in seizures found with DTaP vaccine, new REMS for quinine.
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Vital exhaustion predicts long-term risk for adverse cardiac events in men and women, independent of established biomedical risk factors.
