Neurology
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Apolipoprotein E and CSF Levels in Men and Women With Alzheimer’s Disease
Apolipoprotein E epsilon 4 (APOE4) genotype, the stronger genetic risk factor for late-onset Alzheimer’s disease, negatively affects cerebrospinal levels of tau protein in a sex-dependent manner, whereby the effect of APOE4 is stronger in women than men.
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Utility of Ictal Magnetoencephalography for Identifying Seizure Onset Zone
In a review of 377 magnetoencephalography (MEG) studies in epilepsy patients undergoing presurgical workup, 44 patients were found to have one or more seizures during routine recordings, lasting up to a mean of 51.2 minutes. Ictal MEG provided unique localizing data in about one-third of patients. For patients with frequent seizures or reliably induced seizures, MEG may be a useful supplemental tool for medically refractory epilepsy patients undergoing presurgical evaluation.
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Effect of Sleep on Levodopa-Induced Dyskinesia in Parkinson’s Disease
Parkinson’s disease is associated with sleep disorders commonly. Disrupted sleep patterns appear to make dyskinesias worse in patients treated with levodopa therapy.
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Omadacycline Injection and Tablets (Nuzyra)
The FDA has approved a broad-spectrum antibiotic for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.
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Nocturia: Does Salt Intake Play a Role?
Researchers suggest that excessive salt intake can contribute to urinary frequency and nocturia.
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Exercise Improves Physical Function in Patients With Knee Osteoarthritis
Tailored exercise therapy can improve physical functioning in patients with knee osteoarthritis and comorbid conditions.
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Limited English Proficiency Associated With Significant Differences in End-of-Life Care
In a retrospective cohort study, patients with limited English proficiency had lower rates of do not resuscitate orders, comfort measures orders, and advance directives; higher rates of receiving certain types of life support; and longer hospital stays compared to their English-speaking counterparts.
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The Mediterranean Diet Keeps the Mind Sharp
Italian seniors who ate a high-quality Mediterranean diet exhibited better cognitive function than those who did not.
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Initial Management of Patients With Medication-Overuse Headache
As part of a randomized treatment trial for medication-overuse headache, a simple protocol that provided early advice on stopping excessive medications was effective in one-third of patients, even before any prophylactic medications were started.
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What Does the Sinus P Look Like?
The ECG in the figure was obtained from a woman in her 50s who complained of intermittent chest discomfort in recent weeks. She was hemodynamically stable at the time this tracing was obtained. How might one interpret the ECG?