Neurology/Neurosurgery General
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Neurologic, Cardiovascular Conditions Most Common Diagnostic Errors in ED Claims
In an analysis of 326 closed claims from 2014-2019, researchers found 31% involved either the neurologic or vascular systems. Most diagnostic errors involved one of three issues: Ordering of diagnostic tests (53%), consult management (33%), or ongoing assessment (32%).
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Therapeutic Hypothermia in Coma After Cardiac Arrest With Nonshockable Rhythm
Therapeutic hypothermia is beneficial and increases the probability of brain recovery in patients with coma due to cardiac arrest with a nonshockable heart rhythm.
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Immune Cell Infiltration Drives Cerebral Edema in Glioblastoma
Accumulating evidence suggests that immune dysregulation by glioblastoma cells induces tumor-associated edema and that disruption of this tumor-immune interaction may represent a novel strategy to reduce cerebral edema in glioblastoma.
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Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis
In this prospective, population-based study, mean lifetime heritability of amyotrophic lateral sclerosis was 52% in the entire cohort and 37% in patients devoid of any known pathogenic mutations. The highest heritability was seen in mother-daughter parings in both groups.
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Spontaneous Anterior Interosseous Nerve Syndrome
Anterior interosseous nerve syndrome is part of the median neuropathy spectrum and often has been attributed to compression near the elbow. Modern magnetic resonance neurography and ultrasound studies have ruled-out compression in most cases.
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Diagnostic Criteria for Small Fiber Neuropathy
Multiple clinical tools have emerged to assess small fiber nerve dysfunction, but validated diagnostic criteria are needed to optimize diagnostic sensitivity, support clinical management, and facilitate patient selection for clinical trials.
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Does a Repeat Course of IVIg Help in Severe Guillain-Barré Syndrome?
In an open-label, non-randomized clinical trial using a second course of intravenous immunoglobulin (IVIg) to treat patients with Guillain-Barré syndrome, no benefit was observed. A single course of 2 g/kg of IVIg should be administered. No additional treatment is helpful.
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Stereotactic Radiosurgery for the Treatment of Cerebral Cavernous Malformations
In this comprehensive review of studies comparing treatments for cerebral cavernous malformations, there were no randomized or blinded outcome trials, and the most effective treatment remains uncertain.
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The Role of Muscle MRI in the Diagnosis of Motor Neuron Diseases
The current study characterizes novel patterns of abnormalities on muscle magnetic resonance imaging (MRI) in patients with amyotrophic lateral sclerosis and spinobulbar muscular atrophy. Further, MRI changes correlate with disease severity.
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Stopping Cannabis Improves Cognitive Function in Patients With Multiple Sclerosis
The authors of a recent study evaluated the effect of discontinuing cannabis use in patients with multiple sclerosis. Stopping cannabis led to significant improvements in memory, processing speed, and executive function.