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Multimodal brain imaging demonstrates extensive frontostriatal dysfunction in mild cognitive impairment in early Parkinson's disease.
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An alternate-day steroid protocol appears to be just as efficacious as every-day steroids over the long term in a group of patients with undifferentiated polymyositis, with less serious long-term side effects.
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In this well-designed, randomized, placebo-controlled clinical trial of antioxidant supplements for Alzheimer's disease, there was no benefit, and some agents were associated with worse outcome.
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The incidence of epileptic seizures is much higher in elderly patients with Alzheimer's disease than those who are elderly but non-demented.
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Basilar artery occlusion (BAO) is a grave form of ischemic stroke that carries a high morbidity and mortality. The Basilar Artery International Cooperation Study (BASICS) is a prospective, observational, international registry of consecutive patients with BAO that was radiologically confirmed.
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Early cessation of prehospital seizures via an intramuscular injection of midazolam was at least noninferior, if not superior, to traditional intravenous lorazepam.
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In comatose survivors of cardiac arrest, early malignant EEG findings during therapeutic hypothermia correlated with higher serum neuron-specific enolase levels and poor neurologic outcome.
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Krabbe disease can rarely present in adults as a combined central nervous system disorder with polyneuropathy.
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Continuation of combination therapy with donepezil and memantine appears to have a long-term beneficial effect for patients with moderate-to-severe Alzheimer's disease.