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Patients originally on interferon beta-1a in the TRANSFORMS study were re-randomized to either 0.5 or 1.25 mg of fingolimod. There was a reduction in relapse rate and MRI activity in patients that switched to fingolimod without an increase in severe adverse events.
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Variant Creutzfeldt-Jakob disease usually presents with subtle psychiatric symptoms and there is usually a significant delay in diagnosis.
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With the advent of new vaccines, the incidence of bacterial meningitis has declined, particularly in children, but the mortality rate has remained the same.
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Frontal lobe dysfunction may presdispose people to have psychogenic nonepileptic seizures; this dysfunction can be measured by analyzing a brief period of the awake EEG.
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The King-Devick test, if validated in future studies, has the potential of becoming a standard sideline method for identifying athletes who have sustained a brain injury.
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Anti-neuronal antibodies can be detected in Sydenham's chorea, but not in PANDAS or Tourette's syndrome.
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Primary systemic amyloidosis is often complicated by painful, sensory, and autonomic neuropathy.
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Calcium supplements and MI; birth control pills and VTE; ACE inhibitors and breast cancer risk; spending on pharmaceuticals; and FDA actions.
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