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Torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, has been in development by Pfizer for nearly 15 years.
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In addition to previously identified antibodies that cause limbic encephalitis, novel antibodies directed against cell membrane antigens may cause many of the "antibody-negative" cases, and these cases seem to respond favorably to immunosuppressive treatment.
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Although spontaneous intracranial hypotension (SIH) generally causes a benign, self-limited, postural headache, subdural hematomas may occur in SIH with serious sequelae.
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Selected patients with anticoagulation-associated intracerebral hemorrhage may benefit from surgical evacuation.
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Surgery for frontal lobe epilepsy can be very effective in patients with a localized ictal onset zone, focal MRI abnormalities, nocturnal epilepsy and complete resection of the epileptic zone and/or imaging abnormality.
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The clinical presentation of PLS and ALS are similar, and it may be difficult to distinguish them early in the course.
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Recent imaging studies reinforce the classical concept that periodic breathing in acute stroke indicates a large supratentorial infarct or hemorrhage.
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The presence of hippocampal sclerosis, by itself, does not predict the clinical course of temporal lobe epilepsy.
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New combination chemotherapy protocol for malignant glioma improves 6-month progression-free survival for a dismal disease.