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Metman and associates carried out a controlled trial using amantadine to determine whether they could ameliorate chorea. This was based on prior studies showing that N-methyl-D-aspartate antagonists such as dextrophan, dextromethorphan, and amantadine can alleviate levodopa-induced chorea inpatients with parkinsonism.
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Multiple system atrophy (MSA) is a neurodegerative disorder that can take protean forms. In this elegant paper, Tsuda and colleagues show that patients with the cerebellar form of MSA can be distinguished from idiopathic cerebellar degeneration before other signs of autonomic or parkinsonian disability develop.
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In an extremely preliminary report, Mayer and associates present data on 5 patients with basilar artery thromboses treated with a device called Neuronet.
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While hypertension and smoking have been previously associated with aneurysmal subarachnoid hemorrhage, this is the first report of a role for coffee consumption. The methodology of the study, however, begs several further questions.
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No single antigen has yet been identified as the target in all patients with chronic inflammatory demyelinating polyneuropathy, a presumed autoimmune disorder similar to chronic experimental allergic neuritis, where both humoral and cell-mediated immune responses have been documented. Evidence suggests that specific chemokines play a role in pathogenesis.
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The high lifetime prevalence of depression in MS, along with other variants of mood disorder including anxiety and bipolar-affective illness, should make the psychiatric complications of MS a central component of disease management. These studies provide an additional understanding of depression and suicidal behavior in patients with MS.
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Although syncope is common, its epidemiology and prognosis have not been well described. Soteriades and colleagues, therefore, evaluated the incidence, causes, and prognosis of syncope among men and women taking part in the Framingham Heart Study.
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Mesial temporal sclerosis is the most common pathology found in surgical series of patients undergoing temporal lobectomy for pharmacologically intractable focal epilepsy. A better understanding of the mechanisms leading to this neuropathological substrate for temporal lobe epilepsy should provide fundamental insights into the pathophysiology of epileptogenesis.
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MRC/BHF Heart Protection Study of Antioxidant Vitamin Supplementation in 20,536 High-Risk Individuals; Prolonged Erections Produced by Dihydrocodeine & Sildenafil; Effect of Magnesium Supplementation of Blood Pressure; Homocysteine-Lowering Therapy with Folic Acid, Vitamins, and Clinical Outcome after Percutaneous Coronary Intervention; Effect of Cataract Surgery on Motor Vehicle Accidents in Older Adults; Inflammatory Biomarkers, Hormone Replacement Therapy, and Incident Coronary Heart Disease
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Vitamin-Mineral Supplementation and Acute RTI in Elderly; B-Type
Natriuretic Peptide Levels and Outcome in Heart Failure; Companion
Influence During Primary Care Encounters; Handrubbing with
Alcohol-Based Solution vs. Standard Handwashing; Program To Prevent
Functional Decline in Frail Elderly Who Live at Home; Treatment of
Diabetic Neuropathy with Isosorbide Dinitrate Spray
