Neurology Alert
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Update in Treating Neuropathic Pain
In an exhaustive review of the literature with a meta-analysis, the following medications were found to be most efficacious in the treatment of neuropathic pain: gabapentin, pregabalin, serotonin-noradrenaline reuptake inhibitors including duloxetine or venlafaxine, and tricyclic antidepressants.
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‘The Butterfly Effect’ Explains Weather Triggering of Migraine
For about 13% of patients with migraine, a change in weather may be a trigger for some headaches; however, there is no specific perturbation in meteorological measures that is likely to predict a headache.
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Autologous Hematopoietic Stem Cell Transplant for Relapsing-Remitting MS
Interim analysis at 3 years post-treatment of a study of high-dose immunosuppression and autologous hematopoietic stem cell transplant for relapsing remitting-multiple sclerosis demonstrates sustained disease control but also shows potential risks associated with this treatment.
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Is Pediatric-onset Multiple Sclerosis a Neurodegenerative Disorder?
ABSTRACT & COMMENTARY: Pediatric-onset multiple sclerosis compromises age-expected brain growth.
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Report from the International Stroke Conference 2015
Major announcements at the International Stroke Conference 2015 in Nashville, Tennessee, included reports on three trials that compared endovascular clot retrieval for acute ischemic stroke, compared to medical treatment with intravenous thrombolytics alone. -
Predictors of Refractory Status Epilepticus
In a combined derivation and validation study, three independent risk factors for refractory status epilepticus were identified — acute symptomatic cause for seizures, stupor or coma, and a low serum albumin < 35 g/L. -
How Common Are Neuromuscular Disorders?
Synopsis: Although many specific neuromuscular disorders are rare, in aggregate, these all add up to a large number, roughly twice as common as multiple sclerosis, and about the same prevalence as Parkinson’s disease.
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Neuroimaging Differences in Dyslexics: Chicken or Egg?
Neuroanatomical differences in primary sensory cortices may distinguish dyslexic individuals from non-dyslexic individuals, providing a potential biomarker for identifying adults who may be predisposed to developing atypical neurodegenerative disease. -
Take Me Out of the Ball Game: Acute Management and Long-term Consequences of Concussion in Childhood
The developing brain of a child may be particularly susceptible to injury from mild traumatic brain injury, such as a concussion. Recommending a longer period of strict rest after a concussion does not provide additional benefit when compared to consensus guidelines for care after a concussion in children and adolescents. However, in retired former NFL players, exposure to tackle football prior to age 12 is associated with executive dysfunction, memory impairment, and lower estimated verbal IQ later in life. -
Statins and the Neuromuscular System
Statins inhibit the function of 3-hydroy-3-methylglutaryl coenzyme A reductase and are widely used for risk reduction of cardiovascular and cerebrovascular disease. It is estimated that about 10% of patients will discontinue statins due to muscle-related symptoms.