Neurology Alert
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Clinical Features and Treatment Response in Patients with NMO Spectrum Disorders
In a retrospective analysis of 871 relapses in 185 patients with neuromyelitis optica or an neuromyelitis optica spectrum disorder, the authors reported that more than 80% of patients will have a partial or complete remission from their initial course of therapy.
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Carotid Occlusion Rarely Develops from Asymptomatic Carotid Artery Stenosis
The risk of progression to carotid occlusion is well below the risk of carotid stenting or carotid endarterectomy, and intensive medical therapy appears to be preferred for the vast majority of patients with asymptomatic carotid artery stenosis.
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Postmortem Evidence of Limbic, Neocortical, and Basal Ganglia Deficits in Parkinson’s Disease Dementia
Postmortem brain tissue from 15 individuals with Parkinson’s disease dementia was analyzed by high-performance liquid chromatography and immunoassays, revealing widespread deficits in dopamine, serotonin, and noradrenaline innervation.
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Selective Disruption of Thalamo-Cortical Connections in Patients with Disorders of Consciousness — a Possible Biomarker for Cognitive-Motor Dissociation
In this case-control, functional neuroimaging study, the authors developed a novel method to evaluate correlations between integrity of neural circuits involved in overt and covert motor behavior and apply the method to two patients: one with a dissociation of imaging-based vs bedside evidence of command following and one without.
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Neonatal MRI Can Predict Future Academic Difficulties for Children Born Preterm
Neonatal brain MRI can identify structural changes that predict future difficulties in school performance for children who are born preterm.
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Clinical Features and Consequences of Inclusion Body Myositis
Inclusion body myositis, while poorly understood regarding cause, is clearly responsive to physical exercise, and patients should be encouraged to maintain robust physical activity.
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Medication for Acute Low Back — A Randomized Clinical Trial
In a trial comparing naproxyn alone to combinations with cyclobenzaprine or oxycodone/acetaminophen in patients with acute low back pain, there was no difference in outcome after 1 week.
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Every 5-minute Delay in Performing Endovascular Reperfusion Results in 1 out of 100 Patients Having a Worse Disability Outcome
Every 5-minute delay in performing endovascular reperfusion results in 1 out of 100 patients having a worse disability outcome.
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Treatment for Ulnar Neuropathy at the Elbow
In a randomized treatment trial of steroid injection into the cubital tunnel for ulnar neuropathy, there was no difference in outcome compared to placebo.
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Botulinum Toxin and Treatment of Spasticity
AbobotulinumtoxinA is effective at reducing spasticity and reducing disability in patients with upper limb spasticity due to stroke or traumatic brain injury.