Neurology Alert
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Prevalence and Progression of Epilepsy in Adults with Mitochondrial Disease
In a prospective study of 182 consecutive patients at a specialized mitochondrial clinic in the United Kingdom, followed for more than 7 years, recording the initial prevalence of epilepsy, and subsequently tracking occurrences of new seizure activity, status epilepticus, stroke-like episodes, and death during the follow-up period, epilepsy was found to be a common feature of these disorders.
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Pregnancy Outcomes in Patients with Neuromyelitis Optica Spectrum Disorders
Based on a retrospective analysis of an international cohort of women with neuromyelitis optica spectrum disorders who had at least one pregnancy, the authors report a higher risk for miscarriage and preeclampsia in patients who were diagnosed before pregnancy.
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Inflammatory Cerebral Amyloid Angiopathy: Can We Avoid the Biopsy?
Refinement of the imaging criteria for cerebral amyloid angiopathy-related inflammation may increase sensitivity and specificity enough to forgo brain biopsy.
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Small Vessel Disease Often Accompanies Large Vessel Intracranial Atherosclerosis
The SAMMPRIS trial investigated the consequences of medical vs endovascular therapy for the treatment of symptomatic intracranial atherosclerosis, and points out the high prevalence of coexisting small vessel disease with large vessel atherosclerosis.
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Loss of Consciousness at Onset of Aneurysmal SAH: Poor Prognosis
Loss of consciousness at onset of Aneurysmal subarachnoid hemorrhage is an indicator of early brain injury and predicts poor functional outcome or death at 12 months.
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Left Atrial Dysfunction Without Fibrillation Increases Stroke Risk
Lleft atrial abnormalities that do not necessarily result in atrial fibrillation, may also increase the risk of stroke and should be investigated and searched for in patients with ischemic stroke consistent with cardiogenic embolism.
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Vision Problems After Ischemic Stroke: Effects on Quality of Life
Visual impairments are common in stroke survivors and should prompt a careful ophthalmologic evaluation, since many of the problems are ocular and not neurological.
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Acetylcholine Receptor Antibody Testing in Ocular Myasthenia Gravis
More than two-thirds of patients with ocular myasthenia will have a positive antibody test, and a high level may predict progression to generalized disease.
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Simvastatin and Vitamin D for Migraine Prevention
In a randomized, double-blind, placebo-controlled trial of 57 adults with episodic migraine, simvastatin plus vitamin D was effective in the prevention of headache in adults with episodic migraine.
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Disability, Anxiety, and Depression with Medication-overuse Headache
A brief intervention that focuses on patient education can be effective in reducing headache frequency and medication dependency in patients with medication overuse headache.